e-Drug3D

1430

NEPAFENAC

INN
NEPAFENAC

cas 78281-72-8

CLASS

SENSORY
ANTIINFLAMMATORY
NONSTEROIDAL ANTI-INFLAMMATORY (NSAID) PRODRUG
TREATMENT OF PAIN AND INFLAMMATION ASSOCIATED WITH CATARACT SURGERY
CONVERTED BY OCULAR TISSUE HYDROLASES TO AMFENAC
INHIBITOR THE ACTION OF PROSTAGLANDIN H SYNTHASE (CYCLOOXYGENASE)

ROUTE (list)

OPHTHALMIC

ATC code

S01BC10

PK parameters

Tmax 0.5 HOUR

Target

TARGET PROSTAGLANDIN H SYNTHASE (CYCLOOXYGENASE)

DrugCentral

Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2

Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1

Download SDF file

Benzeneacetamide, 2-amino-3-benzoyl-

Formula:
C15H14N2O2

Calculated chemical properties:

MW 254.28
NB_atoms 19
XLogP 1.53
PSA 80.088
NB_HD 4
NB_HA 4
fsp3 0.07
Lipinski(0=no;1=yes) 1

FDA
NDA 021862 (label) INN (NEPAFENAC) NEVANAC (HARROW EYE) APPROVAL= AP YEAR= 2005 NEWMOLECULARENTITY
NDA 203491 (label) INN (NEPAFENAC) ILEVRO (HARROW EYE) APPROVAL= AP YEAR= 2012