e-Drug3D

1426

cas 118072-93-8

CLASS

MUSCULO-SKELETAL SYSTEM
ANTIHYPOCALCEMIC AGENTS
ANTIRESORPTIVES
BISPHOSPHONATES
BONE DENSITY CONSERVATION AGENTS
INHIBITS OSTEOCLASTIC ACTIVITY AND INDUCES OSTEOCLAST APOPTOSIS

ROUTE (list)

INTRAVENOUS IV INJECTION

PK parameters

VD 39 LITER (65 KILOGRAM)
Cl 8.5 LITER / HOUR (65 KILOGRAM)
PPB 40 PERCENT
t1/2 146 HOUR

-

PDB
4KQ5 (CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG AND ZOLEDRONATE)

Ligand code = ZOL (link to the list of PDB complexes)

Download experimental 3D coordinates of ZOL with added hydrogens

MW 268.06
NB_atoms 16
XLogP -3.64
PSA 142.247
NB_HD 1
NB_HA 9
fsp3 0.40
Lipinski(0=no;1=yes) 0

FDA
NDA 021223 (label) INN (ZOLEDRONIC ACID) ZOMETA (NOVARTIS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 021386 (label) INN (ZOLEDRONIC ACID) ZOMETA (NOVARTIS) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 021817 (label) INN (ZOLEDRONIC ACID) RECLAST (SANDOZ) APPROVAL= AP YEAR= 2007
NDA 022080 (label) INN (ZOLEDRONIC ACID) RECLAST (SANDOZ) APPROVAL= AP YEAR= 2007 NEWAPPLICATION
NDA 078533 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (APOTEX INC) APPROVAL= TA YEAR= 2009
NDA 078576 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (TEVA PARENTERAL) APPROVAL= TA YEAR= 2009
NDA 078580 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (TEVA PARENTERAL) APPROVAL= TA YEAR= 2009
NDA 078768 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (BEDFORD LABS) APPROVAL= TA YEAR= 2009 OBSOLETE
NDA 090330 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (PHARMAFORCE) APPROVAL= TA YEAR= 2009
NDA 090709 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (HOSPIRA INC) APPROVAL= TA YEAR= 2010
NDA 091187 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2011
NDA 091364 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2011
NDA 090018 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (SUN PHARMA GLOBAL) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 091170 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (BRECKENRIDGE) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 091186 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2013
NDA 091363 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2013
NDA 201783 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2013
NDA 202828 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (INFORLIFE) APPROVAL= AP YEAR= 2013
NDA 202930 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (GLAND) APPROVAL= AP YEAR= 2013
NDA 201801 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203231 (label) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (INFORLIFE) APPROVAL= AP YEAR= 2013
NDA 202163 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 202182 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2013
NDA 202472 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (ACTAVIS INC) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202571 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 202650 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (MYLAN LABS LTD) APPROVAL= AP YEAR= 2013
NDA 202746 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (SUN PHARMA GLOBAL) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202837 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (HOSPIRA INC) APPROVAL= AP YEAR= 2013
NDA 078475 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (CIPLA LTD) APPROVAL= TA YEAR= 2014
NDA 091493 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2014
NDA 200918 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2014
NDA 202548 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2014
NDA 202923 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (USV) APPROVAL= AP YEAR= 2014
NDA 204051 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (SUN PHARMA GLOBAL) APPROVAL= TA YEAR= 2014
NDA 204138 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (SUN PHARMA GLOBAL) APPROVAL= TA YEAR= 2014
NDA 090621 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (HOSPIRA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204016 (label) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (HOSPIRA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 091516 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2015
NDA 204367 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (APOTEX) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203344 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (PFIZER INC) APPROVAL= TA YEAR= 2016
NDA 204217 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (GLAND) APPROVAL= AP YEAR= 2016
NDA 205279 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2016
NDA 207751 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (EUGIA PHARMA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203841 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017
NDA 205254 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017
NDA 207341 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (BPI LABS) APPROVAL= AP YEAR= 2017
NDA 209125 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (EUGIA PHARMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 210174 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (AMNEAL) APPROVAL= AP YEAR= 2017
NDA 205749 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC (GLAND) APPROVAL= AP YEAR= 2018
NDA 204344 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (DR REDDYS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 208513 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (SHILPA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 209578 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (GLAND) APPROVAL= AP YEAR= 2019
NDA 208968 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (NOVAST LABS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 213371 (pdf not found) INN (ZOLEDRONIC ACID) ZOLEDRONIC ACID (MEITHEAL) APPROVAL= AP YEAR= 2023