e-Drug3D

1422

GANIRELIX

INN
GANIRELIX

cas 124904-93-4

CLASS

HORMONES
GONADOTROPIN-RELEASING HORMONE ANTAGONIST (GNRH ANTAGONIST)
STIMULATES THE SYNTHESIS AND SECRETION OF LUTEINIZING HORMONE (LH) AND FOLLICLE-STIMULATING HORMONE (FSH)

ROUTE (list)

INJECTION

ATC code

H01CC01

PK parameters

F 91.1 PERCENT (250 MICROGRAM)
VD 43.7 LITER
Cl 3.3 LITER / HOUR
PPB 81.9 PERCENT
t1/2 16.2 HOUR

Target

TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR

DrugCentral

Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR

Download SDF file

D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-

Formula:
C80H113ClN18O13

Calculated chemical properties:

MW 1570.33
NB_atoms 112
XLogP 2.27
PSA 406.691
NB_HD 17
NB_HA 31
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 021057 (pdf not found) INN (GANIRELIX ACETATE) GANIRELIX ACETATE (ORGANON USA ORGANON) APPROVAL= AP YEAR= 1999 NEWMOLECULARENTITY
NDA 204246 (pdf not found) INN (GANIRELIX ACETATE) FYREMADEL (SUN PHARM) APPROVAL= AP YEAR= 2018
NDA 212613 (pdf not found) INN (GANIRELIX ACETATE) GANIRELIX ACETATE (AMPHASTAR PHARMS INC) APPROVAL= AP YEAR= 2022
NDA 214996 (pdf not found) INN (GANIRELIX ACETATE) GANIRELIX ACETATE (MEITHEAL) APPROVAL= AP YEAR= 2022
NDA 215658 (pdf not found) INN (GANIRELIX ACETATE) GANIRELIX ACETATE (GLAND) APPROVAL= AP YEAR= 2023
NDA 216075 (pdf not found) INN (GANIRELIX ACETATE) GANIRELIX ACETATE (LUPIN LTD) APPROVAL= AP YEAR= 2023
NDA 218855 (pdf not found) INN (GANIRELIX ACETATE) GANIRELIX ACETATE (QILU) APPROVAL= AP YEAR= 2025
NDA 219454 (pdf not found) INN (GANIRELIX ACETATE) GANIRELIX ACETATE (TRIS PHARMA INC) APPROVAL= AP YEAR= 2025