e-Drug3D
1418
MEQUINOL
DISCONTINUED
INN
MEQUINOL
cas 150-76-5
CLASS
DERMATOLOGICAL
DEPIGMENTANT
SUBSTRATE FOR THE ENZYME TYROSINASE AND ACTS AS A COMPETITIVE INHIBITOR OF THE FORMATION OF MELANIN PRECURSORS
ROUTE (list)
TOPICAL
ATC code
D11AX06
PK parameters
TARGET TYROSINASE
PDB
5K1M (CRYSTAL STRUCTURE OF OXIDIZED SHEWANELLA YELLOW ENZYME 4 (SYE4) IN COMPLEX WITH P-METHOXYPHENOL)
Ligand code = 4KS (link to the list of PDB complexes)
Download experimental 3D coordinates of 4KS with added hydrogens
Tyrosinase UNIPROT P14679 TYR
Formula:
C7H8O2
Calculated chemical properties:
MW 124.13
NB_atoms 9
XLogP 1.40
PSA 32.39
NB_HD 1
NB_HA 2
fsp3 0.14
Lipinski(0=no;1=yes) 1
NB_atoms 9
XLogP 1.40
PSA 32.39
NB_HD 1
NB_HA 2
fsp3 0.14
Lipinski(0=no;1=yes) 1
FDA
NDA 020922 (pdf not found) INN (MEQUINOL ; TRETINOIN) SOLAGE (ALMIRALL) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 020922 (pdf not found) INN (MEQUINOL ; TRETINOIN) SOLAGE (ALMIRALL) APPROVAL= AP YEAR= 1999 DISCONTINUED