e-Drug3D

1417

cas 54573-75-0

CLASS

HORMONES
SYNTHETIC VITAMIN D2 ANALOG
VITAMIN D PROHORMONE
PARATHYROID HORMONE REGULATOR
CALCIUM REGULATOR

ROUTE (list)

ORAL INJECTION

PK parameters

TARGET VITAMIN D3 RECEPTOR

PDB
3DL9 (CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITH 1-ALPHA-HYDROXY-VITAMIN D2)

Ligand code = V2H (link to the list of PDB complexes)

Download experimental 3D coordinates of V2H with added hydrogens

MW 412.63
NB_atoms 30
XLogP 6.61
PSA 42.036
NB_HD 2
NB_HA 2
fsp3 0.71
Lipinski(0=no;1=yes) 0

FDA
NDA 020862 (label) INN (DOXERCALCIFEROL) HECTOROL (SANOFI) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021027 (label) INN (DOXERCALCIFEROL) HECTOROL (SANOFI) APPROVAL= AP YEAR= 2000
NDA 090040 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (COBREK PHARMA) APPROVAL= TA YEAR= 2011
NDA 091433 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (HIKMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091101 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (HIKMA) APPROVAL= AP YEAR= 2013
NDA 091333 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (SANDOZ) APPROVAL= AP YEAR= 2014
NDA 200926 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (SANDOZ) APPROVAL= AP YEAR= 2014
NDA 203929 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 201518 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (RISING) APPROVAL= AP YEAR= 2016
NDA 208974 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (AMNEAL) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208975 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (AMNEAL) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208614 (label) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (HOSPIRA) APPROVAL= AP YEAR= 2018
NDA 210801 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (LUPIN LTD) APPROVAL= AP YEAR= 2018
NDA 203875 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (SUN PHARM) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210452 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (GLAND) APPROVAL= AP YEAR= 2019
NDA 211670 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (MEITHEAL) APPROVAL= AP YEAR= 2020
NDA 205360 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (AVET) APPROVAL= AP YEAR= 2020
NDA 213717 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (EUGIA PHARMA) APPROVAL= AP YEAR= 2022
NDA 215810 (pdf not found) INN (DOXERCALCIFEROL) DOXERCALCIFEROL (ALEMBIC) APPROVAL= AP YEAR= 2023