e-Drug3D
1415
NALMEFENE
INN
NALMEFENE
cas 55096-26-9
CLASS
NERVOUS SYSTEM
NARCOTIC OPIOID ANTAGONIST
PREVENTS OR REVERSES THE EFFECTS OF OPIOIDS, INCLUDING RESPIRATORY DEPRESSION, SEDATION, AND HYPOTENSION
ROUTE (list)
INTRAMUSCULAR INTRAVENOUS SUBCUTANEOUS NASAL
ATC code
N07BB05
PK parameters
F 99 PERCENT
VD 559 LITER (65 KILOGRAM)
Cl 52 LITER / HOUR (65 KILOGRAM)
PPB 45 PERCENT
t1/2 10.8 HOUR
Solubility
FREELY SOLUBLE IN WATER UP TO 130 MILLIGRAM / MILLILITER
TARGET OPIOID RECEPTOR
Mu-type opioid receptor UNIPROT P35372 OPRM1
Kappa-type opioid receptor UNIPROT P41145 OPRK1
Formula:
C21H25NO3
Calculated chemical properties:
MW 339.42
NB_atoms 25
XLogP 2.51
PSA 55.51
NB_HD 2
NB_HA 4
fsp3 0.62
Lipinski(0=no;1=yes) 1
NB_atoms 25
XLogP 2.51
PSA 55.51
NB_HD 2
NB_HA 4
fsp3 0.62
Lipinski(0=no;1=yes) 1
FDA
NDA 020459 (label) INN (NALMEFENE HYDROCHLORIDE) REVEX (HIKMA) APPROVAL= AP YEAR= 1995 NEWMOLECULARENTITY DISCONTINUED
NDA 212955 (pdf not found) INN (NALMEFENE HYDROCHLORIDE) NALMEFENE HYDROCHLORIDE (PURDUE PHARMA LP) APPROVAL= AP YEAR= 2022
NDA 217470 (label) INN (NALMEFENE HYDROCHLORIDE) OPVEE (INDIVIOR) APPROVAL= AP YEAR= 2023
NDA 216007 (pdf not found) INN (NALMEFENE HYDROCHLORIDE) NALMEFENE HYDROCHLORIDE (CHENGDU SHUODE) APPROVAL= AP YEAR= 2023
NDA 218590 (label) INN (NALMEFENE HYDROCHLORIDE) ZURNAI AUTOINJECTOR (PURDUE PHARMA LP) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 020459 (label) INN (NALMEFENE HYDROCHLORIDE) REVEX (HIKMA) APPROVAL= AP YEAR= 1995 NEWMOLECULARENTITY DISCONTINUED
NDA 212955 (pdf not found) INN (NALMEFENE HYDROCHLORIDE) NALMEFENE HYDROCHLORIDE (PURDUE PHARMA LP) APPROVAL= AP YEAR= 2022
NDA 217470 (label) INN (NALMEFENE HYDROCHLORIDE) OPVEE (INDIVIOR) APPROVAL= AP YEAR= 2023
NDA 216007 (pdf not found) INN (NALMEFENE HYDROCHLORIDE) NALMEFENE HYDROCHLORIDE (CHENGDU SHUODE) APPROVAL= AP YEAR= 2023
NDA 218590 (label) INN (NALMEFENE HYDROCHLORIDE) ZURNAI AUTOINJECTOR (PURDUE PHARMA LP) APPROVAL= AP YEAR= 2024 DISCONTINUED