e-Drug3D

141

RESERPINE

DISCONTINUED


INN
RESERPINE

cas 50-55-5
CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE AGENTS
ANTIPSYCHOTIC AGENTS
DEPLETES MONOAMINES FROM THE BRAIN AND OTHER TISSUES

ROUTE (list)

ORAL INJECTION

NATURAL MOLECULE (link)

ATC code

C02AA02
C02LA01
C02LA51
C02LA71
C02AA52

PK parameters

F 50 PERCENT
Tmax 2.5 HOUR
PPB 95 PERCENT
t1/2 200 HOUR

Solubility

INSOLUBLE IN WATER


Target

-

PDB
8JTC (HUMAN VMAT2 COMPLEX WITH RESERPINE)

Ligand code = YHR (link to the list of PDB complexes)

Download experimental 3D coordinates of YHR with added hydrogens

DrugCentral

Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2

Download SDF file Yohimban-16-carboxylic acid,11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-,methyl ester,(3.beta.,16.beta.,17.alpha.,18.beta.,20.alpha.)-

Formula:
C33H40N2O9

Calculated chemical properties:

MW 608.67
NB_atoms 44
XLogP 4.17
PSA 102.43
NB_HD 1
NB_HA 11
fsp3 0.52
Lipinski(0=no;1=yes) 0

FDA
NDA 009357 (pdf not found) INN (RESERPINE) RAU-SED (BRISTOL MYERS SQUIBB) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009376 (pdf not found) INN (RESERPINE) SANDRIL (LILLY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009391 (pdf not found) INN (RESERPINE) SERPANRAY (PANRAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009453 (pdf not found) INN (RESERPINE) SERPATE (VALE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009627 (pdf not found) INN (RESERPINE) RESERPINE (IMPAX LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009631 (pdf not found) INN (RESERPINE) HISERPIA (BOWMAN PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009645 (pdf not found) INN (RESERPINE) SERPIVITE (VITARINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009663 (pdf not found) INN (RESERPINE) RESERPINE (BUNDY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009859 (pdf not found) INN (RESERPINE) RESERPINE (CYCLE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011185 (pdf not found) INN (RESERPINE) RESERPINE (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012972 (pdf not found) INN (RESERPINE ; TRICHLORMETHIAZIDE) METATENSIN #2 (SANOFI AVENTIS US) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 013927 (pdf not found) INN (QUINETHAZONE ; RESERPINE) HYDROMOX R (LEDERLE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080582 (pdf not found) INN (RESERPINE) RESERPINE (PVT FORM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080637 (pdf not found) INN (RESERPINE) RESERPINE (REXALL) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080753 (pdf not found) INN (RESERPINE) RESERPINE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083058 (pdf not found) INN (RESERPINE) RESERPINE (BELL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083145 (pdf not found) INN (RESERPINE) RESERPINE (ELKINS SINN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083770 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE AND HYDRALAZINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084603 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (ROXANE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084663 (pdf not found) INN (RESERPINE) RESERPINE (PHARMAVITE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084974 (pdf not found) INN (RESERPINE) RESERPINE (MYLAN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085207 (pdf not found) INN (RESERPINE) RESERPINE (TABLICAPS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085317 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085775 (pdf not found) INN (RESERPINE) RESERPINE (PVT FORM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085893 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) UNIPRES (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086117 (pdf not found) INN (RESERPINE) RESERPINE (PVT FORM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086298 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) UNIPRES (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 087085 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) HYDRALAZINE HYDROCHLORIDE-HYDROCHLOROTHIAZIDE-RESERPINE (MYLAN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 087210 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) SER-A-GEN (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088110 (pdf not found) INN (HYDROFLUMETHIAZIDE ; RESERPINE) HYDROFLUMETHIAZIDE AND RESERPINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088127 (pdf not found) INN (HYDROFLUMETHIAZIDE ; RESERPINE) HYDROFLUMETHIAZIDE AND RESERPINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088151 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088195 (pdf not found) INN (HYDROFLUMETHIAZIDE ; RESERPINE) HYDROFLUMETHIAZIDE AND RESERPINE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088376 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE, HYDRALAZINE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009296 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; RESERPINE) SERPASIL-APRESOLINE (NOVARTIS) APPROVAL= AP YEAR= 1954 DISCONTINUED
NDA 009434 (pdf not found) INN (RESERPINE) SERPASIL (NOVARTIS) APPROVAL= AP YEAR= 1954 DISCONTINUED
NDA 009115 (pdf not found) INN (RESERPINE) SERPASIL (NOVARTIS) APPROVAL= AP YEAR= 1955 DISCONTINUED
NDA 009838 (pdf not found) INN (RESERPINE) RESERPINE (SANDOZ) APPROVAL= AP YEAR= 1955 DISCONTINUED
NDA 010124 (pdf not found) INN (RESERPINE) SERPALAN (LANNETT) APPROVAL= AP YEAR= 1955 DISCONTINUED
NDA 011635 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) DIUPRES-250 (MERCK) APPROVAL= AP YEAR= 1958 DISCONTINUED
NDA 011878 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) SERPASIL-ESIDRIX #1 (NOVARTIS) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 012193 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) SER-AP-ES (NOVARTIS) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 012265 (pdf not found) INN (RESERPINE ; TRICHLORMETHIAZIDE) NAQUIVAL (SCHERING) APPROVAL= AP YEAR= 1960 NEWMOLECULARENTITY DISCONTINUED
NDA 012359 (pdf not found) INN (HYDROFLUMETHIAZIDE ; RESERPINE) SALUTENSIN (SHIRE) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 013636 (pdf not found) INN (POLYTHIAZIDE ; RESERPINE) RENESE-R (PFIZER) APPROVAL= AP YEAR= 1963 DISCONTINUED
NDA 015103 (pdf not found) INN (CHLORTHALIDONE ; RESERPINE) REGROTON (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 080393 (pdf not found) INN (RESERPINE) RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 080446 (pdf not found) INN (RESERPINE) RESERPINE (SOLVAY) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080457 (pdf not found) INN (RESERPINE) RESERPINE (HALSEY) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080525 (pdf not found) INN (RESERPINE) RESERPINE (MK LABS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080679 (pdf not found) INN (RESERPINE) RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080721 (pdf not found) INN (RESERPINE) RESERPINE (BARR) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080975 (pdf not found) INN (RESERPINE) RESERPINE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080492 (pdf not found) INN (RESERPINE) RESERPINE (MARSHALL PHARMA) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080723 (pdf not found) INN (RESERPINE) RESERPINE (WHITEWORTH TOWN PLSN) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080749 (pdf not found) INN (RESERPINE) RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083568 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083571 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083572 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083573 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 011958 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROPRES 25 (MERCK) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 012708 (pdf not found) INN (METHYCLOTHIAZIDE ; RESERPINE) DIUTENSEN-R (MEDPOINTE PHARM HLC) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 083877 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROSERPINE PLUS R-H-H (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084291 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) HYDRALAZINE HYDROCHLORIDE, HYDROCHLOROTHIAZIDE AND RESERPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084579 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE AND HYDROCHLOROTHIAZIDE (BARR) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084580 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE AND HYDROCHLOROTHIAZIDE (BARR) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 009667 (pdf not found) INN (RESERPINE) RESERPINE (VALEANT PHARM INTL) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084466 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 084467 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085401 (pdf not found) INN (RESERPINE) RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085420 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (PHARMERAL) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085421 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (PHARMERAL) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085549 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE, HYDRALAZINE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 010441 (pdf not found) INN (RESERPINE) RESERPINE (EVERYLIFE) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 085338 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) H.R.-50 (WHITEWORTH TOWN PLSN) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 085771 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) HYDRALAZINE, HYDROCHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 086330 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 086331 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 084714 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDRO-RESERP (ABC HOLDING) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 084897 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) CAM-AP-ES (CHARTWELL RX) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 010012 (pdf not found) INN (RESERPINE) SANDRIL (LILLY) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 084827 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDRO-SERP "25" (SANDOZ) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 085213 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDRO-SERP "50" (SANDOZ) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 087556 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE, HYDRALAZINE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 083666 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) HYDROCHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087744 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE-RESERPINE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087745 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE-RESERPINE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 084853 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 084876 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) HYDRAP-ES (SANDOZ) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 085248 (pdf not found) INN (RESERPINE ; TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 087709 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE, HYDROCHLOROTHIAZIDE, AND HYDRALAZINE HYDROCHLORIDE (LEDERLE) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088365 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE AND RESERPINE (HIKMA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088557 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE AND RESERPINE (HIKMA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088189 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE AND HYDROCHLOROTHIAZIDE-50 (WEST WARD) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088200 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE AND HYDROCHLOROTHIAZIDE (SANDOZ) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088570 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE ; RESERPINE) RESERPINE, HYDRALAZINE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088907 (pdf not found) INN (HYDROFLUMETHIAZIDE ; RESERPINE) RESERPINE AND HYDROFLUMETHIAZIDE (PAR PHARM) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088932 (pdf not found) INN (HYDROFLUMETHIAZIDE ; RESERPINE) RESERPINE AND HYDROFLUMETHIAZIDE (IVAX PHARMS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089019 (pdf not found) INN (RESERPINE) RESERPINE (TEVA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089020 (pdf not found) INN (RESERPINE) RESERPINE (TEVA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 084617 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; RESERPINE) DRALSERP (SANDOZ) APPROVAL= AP YEAR= 1994 DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL