e-Drug3D

1409

LODOXAMIDE

DISCONTINUED

INN
LODOXAMIDE

cas 53882-12-5

CLASS

SENSORY
ANTIASTHMATIC
ANTIALLERGIC
MAST CELL STABILIZER
VERNAL KERATOCONJUNCTIVITIS

ROUTE (list)

OPHTHALMIC

ATC code

S01GX05

PK parameters

t1/2 8.5 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET G PROTEIN-COUPLED RECEPTOR GPR35 (PMID24113750)

PDB
8H8J (LODOXAMIDE-BOUND GPR35 IN COMPLEX WITH G13)

Download experimental 3D coordinates of WYB with added hydrogens

G-protein coupled receptor 35 UNIPROT Q9HC97 GPR35

Download SDF file

Acetic acid, 2,2'-[(2-chloro-5-cyano-1,3-phenylene)diimino]bis[2-oxo-

Formula:
C11H6ClN3O6

Calculated chemical properties:

MW 309.62
NB_atoms 21
XLogP -2.41
PSA 144.394
NB_HD 2
NB_HA 9
fsp3 0.00
Lipinski(0=no;1=yes) 0

FDA
NDA 020191 (pdf not found) INN (LODOXAMIDE TROMETHAMINE) ALOMIDE (NOVARTIS) APPROVAL= AP YEAR= 1993 NEWMOLECULARENTITY DISCONTINUED