e-Drug3D
1403
FLUTICASONE FUROATE
INN
FLUTICASONE FUROATE
cas 397864-44-7
CLASS
RESPIRATORY
ANTIINFLAMMATORY
CORTICOSTEROIDS AGONIST
TREATMENT OF SYMPTOMS OF SEASONAL AND PERENNIAL ALLERGIC RHINITIS
ROUTE (list)
NASAL INHALATION
PK parameters
F 1.26 PERCENT
VD 608 LITER
Cl 58.7 LITER / HOUR
PPB 99 PERCENT
t1/2 15.1 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET HUMAN GLUCOCORTICOID RECEPTOR
PDB
3CLD (LIGAND BINDING DOMAIN OF THE GLUCOCORTICOID RECEPTOR COMPLEXED WITH FLUTICAZONE FUROATE)
Ligand code = GW6 (link to the list of PDB complexes)
Download experimental 3D coordinates of GW6 with added hydrogens
Glucocorticoid receptor UNIPROT P04150 NR3C1
Formula:
C27H29F3O6S
Calculated chemical properties:
MW 538.57
NB_atoms 37
XLogP 4.93
PSA 75.741
NB_HD 1
NB_HA 6
fsp3 0.59
Lipinski(0=no;1=yes) 0
NB_atoms 37
XLogP 4.93
PSA 75.741
NB_HD 1
NB_HA 6
fsp3 0.59
Lipinski(0=no;1=yes) 0
FDA
NDA 022051 (label) INN (FLUTICASONE FUROATE) FLONASE SENSIMIST ALLERGY RELIEF (HALEON US HOLDINGS) APPROVAL= AP YEAR= 2007
NDA 204275 (label) INN (FLUTICASONE FUROATE ; VILANTEROL TRIFENATATE) BREO ELLIPTA (GLAXO GRP LTD) APPROVAL= AP YEAR= 2013 NEWMOLECULARENTITY
NDA 205625 (label) INN (FLUTICASONE FUROATE) ARNUITY ELLIPTA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2014
NDA 209482 (label) INN (FLUTICASONE FUROATE ; UMECLIDINIUM BROMIDE ; VILANTEROL TRIFENATATE) TRELEGY ELLIPTA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2017
NDA 022051 (label) INN (FLUTICASONE FUROATE) FLONASE SENSIMIST ALLERGY RELIEF (HALEON US HOLDINGS) APPROVAL= AP YEAR= 2007
NDA 204275 (label) INN (FLUTICASONE FUROATE ; VILANTEROL TRIFENATATE) BREO ELLIPTA (GLAXO GRP LTD) APPROVAL= AP YEAR= 2013 NEWMOLECULARENTITY
NDA 205625 (label) INN (FLUTICASONE FUROATE) ARNUITY ELLIPTA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2014
NDA 209482 (label) INN (FLUTICASONE FUROATE ; UMECLIDINIUM BROMIDE ; VILANTEROL TRIFENATATE) TRELEGY ELLIPTA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2017