e-Drug3D

1401

HISTRELIN

INN
HISTRELIN

cas 76712-82-8

CLASS

GONADOTROPIN RELEASING HORMONE (GNRH) AGONIST
HORMONES
TREATMENT OF ADVANCED PROSTATE CANCER INHIBITOR OF GONADOTROPIN SECRETION
TRANSIENT INCREASE IN CONCENTRATION OF GONADAL STEROIDS (TESTOSTERONE AND DIHYDROTESTOSTERONE IN MALES)
TREATMENT OF PRECOCIOUS PUBERTY

ROUTE (list)

INJECTION SUBCUTANEOUS

ATC code

L02AE05

PK parameters

F 92 PERCENT
VD 58.4 LITER
Cl 10.7 LITER / HOUR
PPB 70.5 PERCENT
t1/2 3.92 HOUR

Target

TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR

DrugCentral

Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR

Download SDF file

5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-Ntbenzyl-D-histidyl-Lleucyl-L-arginyl-N-ethyl-L-prolinamide acetate

Formula:
C66H86N18O12

Calculated chemical properties:

MW 1324.54
NB_atoms 96
XLogP -2.61
PSA 400.097
NB_HD 18
NB_HA 29
fsp3 0.44
Lipinski(0=no;1=yes) 0

FDA
NDA 019836 (pdf not found) INN (HISTRELIN ACETATE) SUPPRELIN (SHIRE) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED
NDA 021732 (label) INN (HISTRELIN ACETATE) VANTAS (ENDO OPERATIONS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 022058 (label) INN (HISTRELIN ACETATE) SUPPRELIN LA (ENDO OPERATIONS) APPROVAL= AP YEAR= 2007