e-Drug3D

1400

ACRIVASTINE

DISCONTINUED

INN
ACRIVASTINE

cas 87848-99-5

CLASS

RESPIRATORY
ANTIHISTAMINE
HISTAMINE H1-RECEPTOR ANTAGONIST
TREATMENT OF CHRONIC URTICARIA AND ALLERGIC RHINITIS

ROUTE (list)

ORAL

ATC code

R06AX18

PK parameters

Tmax 1.14 HOUR
VD 29.9 LITER (65 KILOGRAM)
Cl 11.3 LITER / HOUR (65 KILOGRAM)
PPB 50 PERCENT
t1/2 1.9 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET HISTAMINE H1-RECEPTOR (PMID1715267)

DrugCentral

Histamine H1 receptor UNIPROT P35367 HRH1

Download SDF file

2-Propenoic acid, 3-[6-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-2-pyridinyl]-, (2E)-

Formula:
C22H24N2O2

Calculated chemical properties:

MW 347.42
NB_atoms 26
XLogP 2.68
PSA 50.526
NB_HD 0
NB_HA 4
fsp3 0.27
Lipinski(0=no;1=yes) 1

FDA
NDA 019806 (pdf not found) INN (ACRIVASTINE ; PSEUDOEPHEDRINE HYDROCHLORIDE) SEMPREX-D (ENDO OPERATIONS) APPROVAL= AP YEAR= 1994 DISCONTINUED