e-Drug3D

1396

ENALAPRILAT

INN
ENALAPRILAT

(is an active metabolite)

cas 76420-72-9

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

ROUTE (list)

INJECTION

ATC code

C09AA02

PK parameters

VD 24.7 LITER (65 KILOGRAM)
Cl 6.2 LITER / HOUR (65 KILOGRAM)
PPB 38 PERCENT
t1/2 11 HOUR

Solubility

SPARINGLY SOLUBLE IN WATER

Target

TARGET ANGIOTENSIN-CONVERTING ENZYME (ACE)

PDB
1UZE (COMPLEX OF THE ANTI-HYPERTENSIVE DRUG ENALAPRILAT AND THE HUMAN TESTICULAR ANGIOTENSIN I-CONVERTING ENZYME)

Ligand code = EAL (link to the list of PDB complexes)

Download experimental 3D coordinates of EAL with added hydrogens

DrugCentral

Angiotensin-converting enzyme UNIPROT P12821 ACE

Download SDF file

L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-

Formula:
C18H24N2O5

Calculated chemical properties:

MW 346.38
NB_atoms 25
XLogP -1.54
PSA 100.09
NB_HD 1
NB_HA 7
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 019309 (label) INN (ENALAPRILAT) VASOTEC (BIOVAIL LABS INTL) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 075456 (pdf not found) INN (ENALAPRILAT) ENALAPRILAT (HOSPIRA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075458 (label) INN (ENALAPRILAT) ENALAPRILAT (HOSPIRA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075571 (pdf not found) INN (ENALAPRILAT) ENALAPRILAT (HOSPIRA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075578 (pdf not found) INN (ENALAPRILAT) ENALAPRILAT (DR REDDYS) APPROVAL= AP YEAR= 2000
NDA 075634 (pdf not found) INN (ENALAPRILAT) ENALAPRILAT (CHARTWELL INJECTABLE) APPROVAL= AP YEAR= 2000
NDA 078687 (pdf not found) INN (ENALAPRILAT) ENALAPRILAT (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2008