e-Drug3D

1395

ETOPOSIDE PHOSPHATE

INN
ETOPOSIDE PHOSPHATE

cas 117091-64-2

CLASS

ANTINEOPLASTIC
NUCLEIC ACID SYNTHESIS INHIBITORS
INDUCTION OF DNA STRAND BREAKS BY AN INTERACTION WITH DNA-TOPOISOMERASE II OR THE FORMATION OF FREE RADICALS

ROUTE (list)

INJECTION

ATC code

L01CB01

PK parameters

Solubility

WATER SOLUBLE ESTER OF ETOPOSIDE

Target

TARGET DNA TOPOISOMERASE 2

DrugCentral

DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A

Download SDF file

Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5-[3,5-dimethoxy-4-(phosphonooxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-.beta.-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-, (5R,5aR,8aR,9S)-

Formula:
C29H33O16P

Calculated chemical properties:

MW 666.51
NB_atoms 46
XLogP -0.16
PSA 216.612
NB_HD 2
NB_HA 16
fsp3 0.55
Lipinski(0=no;1=yes) 0

FDA
NDA 020457 (label) INN (ETOPOSIDE PHOSPHATE) ETOPOPHOS PRESERVATIVE FREE (CHEPLAPHARM) APPROVAL= AP YEAR= 1996
NDA 020906 (pdf not found) INN (ETOPOSIDE PHOSPHATE) ETOPOPHOS PRESERVATIVE FREE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1998 DISCONTINUED