e-Drug3D

1392

cas 1972-08-3

CLASS

METABOLISM
AGONIST
CANNABINOID COMPONENT OF CANNABIS SATIVA L. (MARIJUANA)
ANTIEMETIC
ANTIANOREXIC
APPETITE STIMULANT

ROUTE (list)

ORAL

PK parameters

F 92.5 PERCENT
VD 650 LITER (65 KILOGRAM)
Cl 13 LITER / HOUR (65 KILOGRAM)
PPB 97 PERCENT
t1/2 30.5 HOUR

TARGET CANNABINOID RECEPTOR

PDB
7M6M (FULL LENGTH ALPHA1 GLYCINE RECEPTOR IN PRESENCE OF 32UM TETRAHYDROCANNABINOL)

Ligand code = TCI (link to the list of PDB complexes)

Download experimental 3D coordinates of TCI with added hydrogens

MW 314.45
NB_atoms 23
XLogP 5.74
PSA 27.616
NB_HD 1
NB_HA 2
fsp3 0.62
Lipinski(0=no;1=yes) 0

FDA
NDA 018651 (label) INN (DRONABINOL) MARINOL (ALKEM LABS LTD) APPROVAL= AP YEAR= 1985
NDA 078292 (pdf not found) INN (DRONABINOL) DRONABINOL (SVC PHARMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078501 (pdf not found) INN (DRONABINOL) DRONABINOL (INSYS THERAP) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 079217 (pdf not found) INN (DRONABINOL) DRONABINOL (HIKMA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 205525 (label) INN (DRONABINOL) SYNDROS (BENUVIA OPERATIONS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 201463 (pdf not found) INN (DRONABINOL) DRONABINOL (LANNETT CO INC) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 207421 (pdf not found) INN (DRONABINOL) DRONABINOL (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2020