e-Drug3D

139

MERCAPTOPURINE

INN
MERCAPTOPURINE

cas 50-44-2

CLASS

ANTINEOPLASTIC
TREATMENT OF ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) (DRUG FOR RARE DISEASE IN EUROPE)
ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS
NUCLEIC ACID SYNTHESIS INHIBITORS
PURINE ANALOGUES
MODIFIED BY HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) TO TIMP (THIOINOSINE MONOPHOSPHATE) AND THEN DIVERSES KINASES (INOSINE MONOPHOSPHATE DEHYDROGENASE, GUANOSINE MONOPHOSPHATE SYNTHETASE AND KINASES) WHICH LEAD TO THE INCORPORATION OF 6-THIOGUANINE NUCLEOTIDES (6-TGN) INTO DNA

ROUTE (list)

ORAL

ATC code

L01BB02

PK parameters

VD 65 LITER (65 KILOGRAM)
Cl 58.5 LITER / HOUR (65 KILOGRAM)
PPB 15 PERCENT
t1/2 1 HOUR

Target

TARGET HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT)

DrugCentral

Amidophosphoribosyltransferase UNIPROT Q06203 PPAT

Download SDF file

3,7-dihydropurine-6-thione

Formula:
C5H4N4S

Calculated chemical properties:

MW 152.19
NB_atoms 10
XLogP 1.02
PSA 48.428
NB_HD 2
NB_HA 4
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 009053 (label) INN (MERCAPTOPURINE) PURINETHOL (STASON PHARMS) APPROVAL= AP YEAR= 1953
NDA 040461 (pdf not found) INN (MERCAPTOPURINE) MERCAPTOPURINE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2004
NDA 040528 (pdf not found) INN (MERCAPTOPURINE) MERCAPTOPURINE (HIKMA) APPROVAL= AP YEAR= 2004
NDA 040594 (pdf not found) INN (MERCAPTOPURINE) MERCAPTOPURINE (MYLAN) APPROVAL= AP YEAR= 2005
NDA 205919 (label) INN (MERCAPTOPURINE) PURIXAN (NOVA LABS LTD) APPROVAL= AP YEAR= 2014
NDA 216418 (pdf not found) INN (MERCAPTOPURINE) MERCAPTOPURINE (HIKMA) APPROVAL= AP YEAR= 2025