e-Drug3D

1389

ESTRAMUSTINE PHOSPHATE

DISCONTINUED

INN
ESTRAMUSTINE PHOSPHATE

(has an active metabolite)

cas 4891-15-0

CLASS

ANTINEOPLASTIC
ALKYLATING
TREATMENT OF PATIENTS WITH METASTATIC AND/OR PROGRESSIVE CARCINOMA OF THE PROSTATE

ROUTE (list)

ORAL

ATC code

L01XX11

PK parameters

F 70 PERCENT
Tmax 2 HOUR
VD 7.8 LITER (65 KILOGRAM)
Cl 3.6 LITER / HOUR (65 KILOGRAM)
t1/2 2.4 HOUR

Solubility

READILY SOLUBLE IN WATER

Target

TARGET ESTROGEN RECEPTOR

DrugCentral

Estrogen receptor beta UNIPROT Q92731 ESR2

Download SDF file

Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-, 3-[N,N-bis(2-chloroethyl)carbamate], 17-(dihydrogen phosphate)

Formula:
C23H32Cl2NO6P

Calculated chemical properties:

MW 518.35
NB_atoms 33
XLogP 4.04
PSA 90.975
NB_HD 0
NB_HA 7
fsp3 0.70
Lipinski(0=no;1=yes) 0

FDA
NDA 018045 (label) INN (ESTRAMUSTINE PHOSPHATE SODIUM) EMCYT (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1981 NEWMOLECULARENTITY DISCONTINUED