e-Drug3D

1378

cas 10238-21-8

CLASS

METABOLISM
ANTIDIABETIC
BLOOD-GLUCOSE-LOWERING DRUG BY STIMULATING THE RELEASE OF INSULIN FROM THE PANCREAS
SULFONYLUREA HYPOGLYCEMIC DRUGS

ROUTE (list)

ORAL

PK parameters

VD 5.2 LITER (65 KILOGRAM)
Cl 3.2 LITER / HOUR (65 KILOGRAM)
PPB 97.9 PERCENT
t1/2 10 HOUR

TARGET ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL

PDB
5IFU (CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE (PRORS, PROLINE--TRNA LIGASE) FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH GLYBURIDE)

Ligand code = GBM (link to the list of PDB complexes)

Download experimental 3D coordinates of GBM with added hydrogens

MW 494.00
NB_atoms 33
XLogP 3.64
PSA 108.652
NB_HD 3
NB_HA 8
fsp3 0.39
Lipinski(0=no;1=yes) 1

FDA
NDA 017498 (label) INN (GLYBURIDE) MICRONASE (PFIZER) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 017532 (label) INN (GLYBURIDE) DIABETA (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1984
NDA 020051 (label) INN (GLYBURIDE) GLYNASE (PFIZER) APPROVAL= AP YEAR= 1992
NDA 020055 (pdf not found) INN (GLYBURIDE) GLYBURIDE MICRONIZED (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 074388 (pdf not found) INN (GLYBURIDE) GLYBURIDE (TEVA) APPROVAL= AP YEAR= 1995
NDA 074591 (pdf not found) INN (GLYBURIDE) GLYBURIDE MICRONIZED (STRIDES PHARMA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074792 (pdf not found) INN (GLYBURIDE) GLYBURIDE MICRONIZED (NATCO PHARMA) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075174 (pdf not found) INN (GLYBURIDE) GLYBURIDE MICRONIZED (CHARTWELL RX) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074686 (pdf not found) INN (GLYBURIDE) GLYBURIDE MICRONIZED (TEVA) APPROVAL= AP YEAR= 1999
NDA 021178 (label) INN (GLYBURIDE ; METFORMIN HYDROCHLORIDE) GLUCOVANCE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075947 (pdf not found) INN (GLYBURIDE) GLYBURIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076257 (pdf not found) INN (GLYBURIDE) GLYBURIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2002
NDA 075890 (pdf not found) INN (GLYBURIDE) GLYBURIDE MICRONIZED (HIKMA) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076345 (pdf not found) INN (GLYBURIDE ; METFORMIN HYDROCHLORIDE) GLYBURIDE AND METFORMIN HYDROCHLORIDE (IMPAX LABS INC) APPROVAL= AP YEAR= 2004
NDA 076731 (pdf not found) INN (GLYBURIDE ; METFORMIN HYDROCHLORIDE) GLYBURIDE AND METFORMIN HYDROCHLORIDE (IMPAX LABS INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076716 (pdf not found) INN (GLYBURIDE ; METFORMIN HYDROCHLORIDE) GLYBURIDE AND METFORMIN HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2005
NDA 076821 (pdf not found) INN (GLYBURIDE ; METFORMIN HYDROCHLORIDE) GLYBURIDE AND METFORMIN HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077537 (pdf not found) INN (GLYBURIDE) GLYBURIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077870 (pdf not found) INN (GLYBURIDE ; METFORMIN HYDROCHLORIDE) GLYBURIDE AND METFORMIN HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2007
NDA 079009 (pdf not found) INN (GLYBURIDE ; METFORMIN HYDROCHLORIDE) GLYBURIDE AND METFORMIN HYDROCHLORIDE (HERITAGE) APPROVAL= AP YEAR= 2009
NDA 090937 (pdf not found) INN (GLYBURIDE) GLYBURIDE (HERITAGE) APPROVAL= AP YEAR= 2011
NDA 206079 (pdf not found) INN (GLYBURIDE) GLYBURIDE (IMPAX LABS INC) APPROVAL= AP YEAR= 2015
NDA 203581 (pdf not found) INN (GLYBURIDE) GLYBURIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 206748 (pdf not found) INN (GLYBURIDE ; METFORMIN HYDROCHLORIDE) GLYBURIDE AND METFORMIN HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2016
NDA 206749 (pdf not found) INN (GLYBURIDE) GLYBURIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2016
NDA 203379 (pdf not found) INN (GLYBURIDE) GLYBURIDE (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2019
NDA 206483 (pdf not found) INN (GLYBURIDE) GLYBURIDE (ORIENT PHARMA CO LTD) APPROVAL= AP YEAR= 2019