e-Drug3D

1372

cas 68373-14-8

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
BETA-LACTAMASE INHIBITORS

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

VD 20.8 LITER (65 KILOGRAM)
Cl 19.8 LITER / HOUR (65 KILOGRAM)
PPB 38 PERCENT
t1/2 1 HOUR

TARGET BETA-LACTAMASE

PDB
4FH2 (STRUCTURE OF S70C BETA-LACTAMASE BOUND TO SULBACTAM)

Ligand code = 0RN (link to the list of PDB complexes)

Download experimental 3D coordinates of 0RN with added hydrogens

MW 232.24
NB_atoms 15
XLogP -2.13
PSA 92.418
NB_HD 0
NB_HA 6
fsp3 0.75
Lipinski(0=no;1=yes) 1

FDA
NDA 050608 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) UNASYN (PFIZER) APPROVAL= AP YEAR= 1986
NDA 062901 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) UNASYN (PFIZER) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 065074 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (HIKMA) APPROVAL= AP YEAR= 2002
NDA 065076 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (HIKMA) APPROVAL= AP YEAR= 2002
NDA 065176 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (HQ SPECLT PHARMA) APPROVAL= AP YEAR= 2005
NDA 065188 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (HQ SPECLT PHARMA) APPROVAL= AP YEAR= 2005
NDA 065222 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (ISTITUTO BIO ITA SPA) APPROVAL= AP YEAR= 2005
NDA 065240 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (SANDOZ) APPROVAL= AP YEAR= 2006
NDA 065241 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (SANDOZ) APPROVAL= AP YEAR= 2006
NDA 065310 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (SANDOZ) APPROVAL= AP YEAR= 2006
NDA 065314 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (ISTITUTO BIO ITA SPA) APPROVAL= AP YEAR= 2006
NDA 065316 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (PHARM ASSOC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065403 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (ACS DOBFAR) APPROVAL= AP YEAR= 2009
NDA 065406 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (ACS DOBFAR) APPROVAL= AP YEAR= 2009
NDA 090339 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (EUGIA PHARMA SPECLTS) APPROVAL= AP YEAR= 2010
NDA 090340 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (EUGIA PHARMA SPECLTS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090349 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (EUGIA PHARMA SPECLTS) APPROVAL= AP YEAR= 2010
NDA 090375 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (HOSPIRA INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090646 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (HOSPIRA INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090653 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (HOSPIRA INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 201024 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (STERISCIENCE) APPROVAL= AP YEAR= 2014
NDA 202197 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (STERISCIENCE) APPROVAL= AP YEAR= 2014
NDA 201406 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (ANTIBIOTICE) APPROVAL= AP YEAR= 2015
NDA 090578 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (ASTRAL) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 090579 (pdf not found) INN (AMPICILLIN SODIUM ; SULBACTAM SODIUM) AMPICILLIN AND SULBACTAM (ASTRAL) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 216974 (pdf not found) INN (DURLOBACTAM SODIUM ; DURLOBACTAM SODIUM ; SULBACTAM SODIUM) XACDURO COPACKAGED (ENTASIS THERAP) APPROVAL= AP YEAR= 2023