e-Drug3D

132

METHSCOPOLAMINE

INN
METHSCOPOLAMINE

cas 13265-10-6

CLASS

METABOLISM
ANTICHOLINERGIC
ANTISPASMODICS
PARASYMPATHOLYTICS
MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONIST

ROUTE (list)

ORAL

ATC code

A03BB03
S01FA03
A03CB01

PK parameters

F 17 PERCENT
Tmax 1 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR

PDB
4U16 (M3-MT4L RECEPTOR BOUND TO NMS)

Ligand code = 3C0 (link to the list of PDB complexes)

Download experimental 3D coordinates of 3C0 with added hydrogens

DrugCentral

Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1

Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3

Download SDF file

3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-,(1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-

Formula:
C18H24NO4

Calculated chemical properties:

MW 318.38
NB_atoms 23
XLogP 1.06
PSA 48.838
NB_HD 1
NB_HA 4
fsp3 0.61
Lipinski(0=no;1=yes) 1

FDA
NDA 008848 (pdf not found) INN (METHSCOPOLAMINE BROMIDE) PAMINE (FOUGERA PHARMS) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 080970 (pdf not found) INN (METHSCOPOLAMINE BROMIDE) METHSCOPOLAMINE BROMIDE (PVT FORM) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 040624 (pdf not found) INN (METHSCOPOLAMINE BROMIDE) METHSCOPOLAMINE BROMIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 040642 (pdf not found) INN (METHSCOPOLAMINE BROMIDE) METHSCOPOLAMINE BROMIDE (BRECKENRIDGE PHARM) APPROVAL= AP YEAR= 2011
NDA 200602 (pdf not found) INN (METHSCOPOLAMINE BROMIDE) METHSCOPOLAMINE BROMIDE (UNICHEM) APPROVAL= AP YEAR= 2012
NDA 216786 (pdf not found) INN (METHSCOPOLAMINE BROMIDE) METHSCOPOLAMINE BROMIDE (NE RX PHARMA) APPROVAL= AP YEAR= 2024