e-Drug3D

1318

cas 59-01-8

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
PROTEIN SYNTHESIS INHIBITORS

ROUTE (list)

ORAL INJECTION

PK parameters

VD 16.9 LITER (65 KILOGRAM)
Cl 5.4 LITER / HOUR (65 KILOGRAM)
PPB 1 PERCENT
t1/2 2.1 HOUR

TARGET AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB
KANAMYCIN NUCLEOTIDYLTRANSFERASE

PDB
4FEX (CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR TYRPHOSTIN AG1478)

Ligand code = KAN (link to the list of PDB complexes)

Download experimental 3D coordinates of KAN with added hydrogens

MW 484.51
NB_atoms 33
XLogP -7.29
PSA 267.509
NB_HD 15
NB_HA 15
fsp3 1.00
Lipinski(0=no;1=yes) 0

FDA
NDA 060516 (pdf not found) INN (KANAMYCIN SULFATE) KANTREX (APOTHECON) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061911 (pdf not found) INN (KANAMYCIN SULFATE) KANTREX (APOTHECON) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062170 (pdf not found) INN (KANAMYCIN SULFATE) KLEBCIL (KING PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062466 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (INTL MEDICATION) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062504 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062564 (pdf not found) INN (KANAMYCIN SULFATE) KANTREX (APOTHECON) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062605 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (SOLOPAK) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062642 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062668 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (PHARMAFAIR) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062669 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (PHARMAFAIR) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062672 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (PHARMAFAIR) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 063092 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061655 (pdf not found) INN (KANAMYCIN SULFATE) KANTREX (APOTHECON) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 061901 (pdf not found) INN (KANAMYCIN SULFATE) KANTREX (APOTHECON) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 062324 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN (HIKMA) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 062520 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 062726 (pdf not found) INN (KANAMYCIN SULFATE) KANTREX (APOTHECON) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 063021 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (LOCH) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 063022 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (LOCH) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 063025 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (LOCH) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 065111 (pdf not found) INN (KANAMYCIN SULFATE) KANAMYCIN SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2002 DISCONTINUED