e-Drug3D

1317
CEFOTETAN


INN
CEFOTETAN
cas 69712-56-7
CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
CEPHALOSPORINS
ROUTE (list)

INJECTION

ATC code

J01DC05
PK parameters

VD 10.4 LITER
Cl 1.8 LITER / HOUR
PPB 88 PERCENT
t1/2 3.8 HOUR

Solubility

VERY SOLUBLE IN WATER


Target

TARGET PENICILLIN BINDING PROTEINS (PBPS)

 DrugCentral

Bacterial penicillin-binding protein UNIPROT P02918 mrcA

 Download SDF file (7S)-7-[[4-(1-amino-3-hydroxy-1,3-dioxopropan-2-ylidene)1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Formula:
C17H17N7O8S4

Calculated chemical properties:

MW 573.64
NB_atoms 36
XLogP -4.07
PSA 203.056
NB_HD 3
NB_HA 15
fsp3 0.41
Lipinski(0=no;1=yes) 0

FDA
NDA 050588 (pdf not found) INN (CEFOTETAN DISODIUM) CEFOTAN (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 1985
NDA 050694 (pdf not found) INN (CEFOTETAN DISODIUM) CEFOTAN IN PLASTIC CONTAINER (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 063293 (pdf not found) INN (CEFOTETAN DISODIUM) CEFOTAN (TELIGENT) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 065374 (pdf not found) INN (CEFOTETAN DISODIUM) CEFOTETAN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2007
NDA 065375 (pdf not found) INN (CEFOTETAN DISODIUM) CEFOTETAN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065430 (pdf not found) INN (CEFOTETAN DISODIUM) CEFOTETAN AND DEXTROSE IN DUPLEX CONTAINER (B BRAUN) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 091030 (pdf not found) INN (CEFOTETAN DISODIUM) CEFOTETAN (WEST-WARD PHARM CORP) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091031 (pdf not found) INN (CEFOTETAN DISODIUM) CEFOTETAN (HIKMA) APPROVAL= AP YEAR= 2011 DISCONTINUED

 Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL