e-Drug3D

1313

BLEOMYCIN

INN
BLEOMYCIN

cas 11056-06-7

CLASS

ANTINEOPLASTIC
CYTOTOXIC GLYCOPEPTIDE ANTIBIOTICS ISOLATED FROM A STRAIN OF STREPTOMYCES VERTICILLUS
SEQUENCE SELECTIVE CLEAVAGE OF DNA (PMID25187079)

ROUTE (list)

INJECTION

NATURAL MOLECULE (link)

ATC code

L01DC01

PK parameters

F 72.5 PERCENT
VD 30.2 LITER
Cl 5.2 LITER / HOUR
t1/2 2 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET DNA

PDB
1JIE (BLEOMYCIN-BINDING PROTEIN FROM BLEOMYCIN-PRODUCING STREPTOMYCES VERTICILLUS)

Ligand code = BLM (link to the list of PDB complexes)

Download experimental 3D coordinates of BLM with added hydrogens

DrugCentral

Unknown

Download SDF file

3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium

Formula:
C55H84N17O21S3

Calculated chemical properties:

MW 1415.60
NB_atoms 96
XLogP -7.70
PSA 541.03
NB_HD 25
NB_HA 38
fsp3 0.62
Lipinski(0=no;1=yes) 0

FDA
NDA 050443 (label) INN (BLEOMYCIN SULFATE) BLENOXANE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 064084 (pdf not found) INN (BLEOMYCIN SULFATE) BLEOMYCIN SULFATE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 065031 (pdf not found) INN (BLEOMYCIN SULFATE) BLEOMYCIN SULFATE (HOSPIRA) APPROVAL= AP YEAR= 2000
NDA 065033 (pdf not found) INN (BLEOMYCIN SULFATE) BLEOMYCIN SULFATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 065042 (pdf not found) INN (BLEOMYCIN SULFATE) BLEOMYCIN SULFATE (HIKMA) APPROVAL= AP YEAR= 2001
NDA 065201 (pdf not found) INN (BLEOMYCIN SULFATE) BLEOMYCIN SULFATE (PHARMACHEMIE BV) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065185 (pdf not found) INN (BLEOMYCIN SULFATE) BLEOMYCIN SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2008
NDA 205030 (pdf not found) INN (BLEOMYCIN SULFATE) BLEOMYCIN SULFATE (MEITHEAL) APPROVAL= AP YEAR= 2018
NDA 209439 (pdf not found) INN (BLEOMYCIN SULFATE) BLEOMYCIN SULFATE (CIPLA) APPROVAL= AP YEAR= 2019 DISCONTINUED