e-Drug3D

1312

COLISTIN

INN
COLISTIN

(is an active metabolite)

cas 1066-17-7

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
POLYMYXIN E
DISRUPTS THE BACTERIAL CELL MEMBRANE

ROUTE (list)

ORAL OTIC

ATC code

A07AA10
J01XB01

PK parameters

VD 189 LITER (PMID19433570)
Cl 13.7 LITER / HOUR (PMID19433570)
t1/2 14.4 HOUR (PMID19433570)

Target

TARGET MEMBRANE

DrugCentral

Unknown

Download SDF file

N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-5-methylheptanamide

Formula:
C52H98N16O13

Calculated chemical properties:

MW 1155.46
NB_atoms 81
XLogP -5.83
PSA 443.846
NB_HD 23
NB_HA 29
fsp3 0.79
Lipinski(0=no;1=yes) 0

FDA
NDA 050355 (pdf not found) INN (COLISTIN SULFATE) COLY-MYCIN S (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 050356 (pdf not found) INN (COLISTIN SULFATE ; HYDROCORTISONE ACETATE ; NEOMYCIN SULFATE ; THONZONIUM BROMIDE) COLY-MYCIN S (ENDO PHARMS INC) APPROVAL= AP YEAR= 1962