e-Drug3D

1304

SUNITINIB

INN
SUNITINIB

cas 557795-19-4

CLASS

ANTINEOPLASTIC
ANGIOGENESIS INHIBITORS
KINASE INHIBITOR
TREATMENT OF GASTROINTESTINAL STROMAL TUMOR (GIST), GASTROINTESTINAL STROMAL TUMOR (GIST) AND PANCREATIC NEUROENDOCRINE TUMORS
INHIBITED THE PHOSPHORYLATION OF MULTIPLE RTKS (MULTIPLE RECEPTOR TYROSINE KINASES)

ROUTE (list)

ORAL

ATC code

L01EX01

PK parameters

VD 2230 LITER
Cl 48 LITER / HOUR
PPB 95 PERCENT
t1/2 50 HOUR

Solubility

25 MILLIGRAM / MILLILITER

Target

TARGET OF PLATELET-DERIVED GROWTH FACTOR RECEPTORS (PDGFRALPHA AND PDGFRBETA)
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS (VEGFR1, VEGFR2 AND VEGFR3)
STEM CELL FACTOR RECEPTOR (KIT)
FMS-LIKE TYROSINE KINASE-3 (FLT3)
COLONY STIMULATING FACTOR RECEPTOR TYPE 1 (CSF-1R)
GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR (RET)

PDB
2Y7J (STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2)

Ligand code = B49 (link to the list of PDB complexes)

Download experimental 3D coordinates of B49 with added hydrogens

DrugCentral

Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB

Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT

Download SDF file

N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

Formula:
C22H27FN4O2

Calculated chemical properties:

MW 398.48
NB_atoms 29
XLogP 3.33
PSA 73.779
NB_HD 3
NB_HA 6
fsp3 0.36
Lipinski(0=no;1=yes) 1

FDA
NDA 021938 (label) INN (SUNITINIB MALATE) SUTENT (CPPI CV) APPROVAL= AP YEAR= 2006
NDA 021968 (label) INN (SUNITINIB MALATE) SUTENT (CPPI CV) APPROVAL= AP YEAR= 2006 NEWAPPLICATION
NDA 201275 (label) INN (SUNITINIB MALATE) SUNITINIB MALATE (MYLAN) APPROVAL= AP YEAR= 2021
NDA 213803 (pdf not found) INN (SUNITINIB MALATE) SUNITINIB MALATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2021
NDA 213914 (pdf not found) INN (SUNITINIB MALATE) SUNITINIB MALATE (SUN PHARM) APPROVAL= AP YEAR= 2021
NDA 215843 (pdf not found) INN (SUNITINIB MALATE) SUNITINIB MALATE (DR REDDYS) APPROVAL= AP YEAR= 2022
NDA 218012 (pdf not found) INN (SUNITINIB MALATE) SUNITINIB MALATE (FOSUN WANBANG) APPROVAL= AP YEAR= 2023
NDA 218024 (pdf not found) INN (SUNITINIB MALATE) SUNITINIB MALATE (NATCO PHARMA) APPROVAL= AP YEAR= 2023
NDA 218615 (pdf not found) INN (SUNITINIB MALATE) SUNITINIB MALATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2024
NDA 214824 (pdf not found) INN (SUNITINIB MALATE) SUNITINIB MALATE (MSN) APPROVAL= AP YEAR= 2025