e-Drug3D

1303

SORAFENIB

INN
SORAFENIB

cas 284461-73-0

CLASS

ANTINEOPLASTIC
PROTEIN KINASE INHIBITOR
TREATMENT OF HEPATOCELLULAR CARCINOMA AND RENAL CELL CARCINOMA
MULTIPLE INTRACELLULAR RECEPTOR TYROSINE KINASES
CELL SURFACE KINASES

ROUTE (list)

ORAL

ATC code

L01EX02

PK parameters

F 43.5 PERCENT
Tmax 3 HOUR
PPB 99.5 PERCENT
t1/2 36.5 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET CRAF
BRAF
MUTANT BRAF
KIT
FLT-3
RET
VEGFR-1
VEGFR-2
VEGFR-3
PDGFR-BETA

PDB
1UWJ (THE COMPLEX OF MUTANT V599E B-RAF AND BAY439006.)

Ligand code = BAX (link to the list of PDB complexes)

Download experimental 3D coordinates of BAX with added hydrogens

DrugCentral

Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB

Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT

Download SDF file

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide

Formula:
C21H16ClF3N4O3

Calculated chemical properties:

MW 464.83
NB_atoms 32
XLogP 5.55
PSA 87.342
NB_HD 3
NB_HA 7
fsp3 0.10
Lipinski(0=no;1=yes) 0

FDA
NDA 021923 (pdf not found) INN (SORAFENIB TOSYLATE) NEXAVAR (BAYER HLTHCARE) APPROVAL= AP YEAR= 2005
NDA 207012 (pdf not found) INN (SORAFENIB TOSYLATE) SORAFENIB TOSYLATE (MYLAN) APPROVAL= AP YEAR= 2020
NDA 209567 (pdf not found) INN (SORAFENIB TOSYLATE) SORAFENIB TOSYLATE (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2020
NDA 216073 (pdf not found) INN (SORAFENIB TOSYLATE) SORAFENIB TOSYLATE (DR REDDYS) APPROVAL= AP YEAR= 2022
NDA 209050 (pdf not found) INN (SORAFENIB TOSYLATE) SORAFENIB TOSYLATE (YABAO PHARM) APPROVAL= AP YEAR= 2022
NDA 217095 (pdf not found) INN (SORAFENIB TOSYLATE) SORAFENIB TOSYLATE (TORRENT) APPROVAL= AP YEAR= 2023
NDA 212228 (pdf not found) INN (SORAFENIB TOSYLATE) SORAFENIB TOSYLATE (APOTEX) APPROVAL= AP YEAR= 2025 DISCONTINUED