e-Drug3D

1302

cas 136236-51-6

CLASS

NERVOUS SYSTEM
COGNITION ENHANCER
ANTIPARKINSONIAN
MONOAMINE OXIDASE INHIBITORS
NEUROPROTECTIVE AGENTS

ROUTE (list)

ORAL

PK parameters

F 36 PERCENT
VD 87 LITER
Cl 20 LITER / HOUR (EQN)
PPB 91 PERCENT
t1/2 3 HOUR

TARGET MONOAMINE OXIDASE TYPE A (MAO-A)
MONOAMINE OXIDASE TYPE B (MAO-B)
APOPTOSIS REGULATOR BCL-2
AMINE OXIDASE [FLAVIN-CONTAINING] B

PDB
2C75 (FUNCTIONAL ROLE OF THE AROMATIC CAGE IN HUMAN MONOAMINE OXIDASE B: STRUCTURES AND CATALYTIC PROPERTIES OF TYR435 MUTANT PROTEINS)

Ligand code = RSA (link to the list of PDB complexes)

Download experimental 3D coordinates of RSA with added hydrogens

MW 171.23
NB_atoms 13
XLogP 1.90
PSA 13.683
NB_HD 1
NB_HA 1
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 021641 (label) INN (RASAGILINE MESYLATE) AZILECT (TEVA) APPROVAL= AP YEAR= 2006
NDA 201823 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (WATSON LABS INC) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 201950 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (APOTEX INC) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 201899 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (ALKEM LABS LTD) APPROVAL= TA YEAR= 2015
NDA 201970 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (ORBION PHARMS) APPROVAL= AP YEAR= 2016
NDA 201889 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2017
NDA 201971 (label) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2017
NDA 201892 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (CHARTWELL RX) APPROVAL= AP YEAR= 2018
NDA 207004 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (MICRO LABS) APPROVAL= AP YEAR= 2019
NDA 206153 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (INDOCO) APPROVAL= AP YEAR= 2019
NDA 201942 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (CARNEGIE) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 218163 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (SKG PHARMA) APPROVAL= AP YEAR= 2024
NDA 208866 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 210150 (pdf not found) INN (RASAGILINE MESYLATE) RASAGILINE MESYLATE (TORRENT) APPROVAL= AP YEAR= 2025