e-Drug3D

1301

TETRACAINE

INN
TETRACAINE

cas 94-24-6

CLASS

CARDIOVASCULAR
ANESTHETIC
BLOCKER OF SODIUM ION CHANNELS

ROUTE (list)

TOPICAL OPHTHALMIC NASAL

ATC code

C05AD02
D04AB06
N01BA03
S01HA03
N01BA53

PK parameters

PPB 75 PERCENT

Target

TARGET SODIUM CHANNEL

PDB
4OMW (CRYSTAL STRUCTURE OF GOAT BETA-LACTOGLOBULIN (ORTHORHOMBIC FORM))

Ligand code = TE4 (link to the list of PDB complexes)

Download experimental 3D coordinates of TE4 with added hydrogens

DrugCentral

Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A

Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A

Download SDF file

Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester

Formula:
C15H24N2O2

Calculated chemical properties:

MW 264.36
NB_atoms 19
XLogP 2.62
PSA 44.401
NB_HD 1
NB_HA 4
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 021623 (label) INN (LIDOCAINE ; TETRACAINE) SYNERA (GALEN SPECIALTY) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 021717 (label) INN (LIDOCAINE ; TETRACAINE) PLIAGLIS (TARO PHARMS) APPROVAL= AP YEAR= 2006
NDA 208135 (label) INN (TETRACAINE HYDROCHLORIDE) TETRACAINE HYDROCHLORIDE (ALCON LABS) APPROVAL= AP YEAR= 2016
NDA 208032 (label) INN (OXYMETAZOLINE HYDROCHLORIDE ; TETRACAINE HYDROCHLORIDE) KOVANAZE (ST RENATUS) APPROVAL= AP YEAR= 2016
NDA 210821 (label) INN (TETRACAINE HYDROCHLORIDE) TETRACAINE HYDROCHLORIDE (BAUSCH LOMB IRELAND) APPROVAL= AP YEAR= 2019
NDA 217227 (pdf not found) INN (TETRACAINE HYDROCHLORIDE) TETRACAINE HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024