e-Drug3D

1300

cas 198904-31-3

CLASS

ANTIINFECTIVES
HIV PROTEASE INHIBITOR

ROUTE (list)

ORAL

PK parameters

Tmax 2.5 HOUR
PPB 86 PERCENT
t1/2 7.9 HOUR

TARGET HIV-1 PROTEASE

PDB
3EKW (CRYSTAL STRUCTURE OF THE INHIBITOR ATAZANAVIR (ATV) IN COMPLEX WITH A MULTI-DRUG RESISTANCE HIV-1 PROTEASE VARIANT (L10I, G48V, I54V, V64I, V82A) REFER: FLAP+ IN CITATION)

Ligand code = DR7 (link to the list of PDB complexes)

Download experimental 3D coordinates of DR7 with added hydrogens

MW 704.86
NB_atoms 51
XLogP 4.21
PSA 147.131
NB_HD 5
NB_HA 13
fsp3 0.45
Lipinski(0=no;1=yes) 0

FDA
NDA 021567 (pdf not found) INN (ATAZANAVIR SULFATE) REYATAZ (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2003
NDA 078785 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (EMCURE PHARMA) APPROVAL= TA YEAR= 2008
NDA 091611 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (MATRIX LABS LTD) APPROVAL= TA YEAR= 2010
NDA 200196 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (EMCURE PHARMS) APPROVAL= TA YEAR= 2010
NDA 022282 (pdf not found) INN (ATAZANAVIR SULFATE ; RITONAVIR) ATAZANAVIR SULFATE AND RITONAVIR (MATRIX LABS LTD) APPROVAL= TA YEAR= 2011
NDA 091673 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014
NDA 205508 (pdf not found) INN (ATAZANAVIR SULFATE ; RITONAVIR) ATAZANAVIR SULFATE; RITONAVIR (EMCURE PHARMS LTD) APPROVAL= TA YEAR= 2014
NDA 206041 (pdf not found) INN (ATAZANAVIR SULFATE ; RITONAVIR ; LAMIVUDINE ; ZIDOVUDINE) ATAZANAVIR SULFATE;RITONAVIR;LAMIVUDINE;ZIDOVUDINE (MYLAN LABS LTD) APPROVAL= TA YEAR= 2014
NDA 206352 (pdf not found) INN (ATAZANAVIR SULFATE) REYATAZ (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2014
NDA 206353 (pdf not found) INN (ATAZANAVIR SULFATE ; COBICISTAT) EVOTAZ (BRISTOL) APPROVAL= AP YEAR= 2015
NDA 091641 (pdf not found) INN (ATAZANAVIR) ATAZANAVIR (PHARMACARE LTD) APPROVAL= TA YEAR= 2017 OBSOLETE
NDA 204806 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2018
NDA 200626 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (CIPLA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 208177 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (MYLAN) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209717 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (AMNEAL) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 210575 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212579 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (LAURUS) APPROVAL= AP YEAR= 2021
NDA 212278 (pdf not found) INN (ATAZANAVIR SULFATE) ATAZANAVIR SULFATE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2022