e-Drug3D
1291
CASPOFUNGIN
INN
CASPOFUNGIN
cas 162808-62-0
CLASS
ANTIINFECTIVES
ECHINOCANDIN ANTIFUNGAL
INHIBITOR
ROUTE (list)
INTRAVENOUS
ATC code
J02AX04
PK parameters
VD 8.45 LITER (65 KILOGRAM)
Cl 0.72 LITER / HOUR
PPB 97 PERCENT
t1/2 27 HOUR
Solubility
FREELY SOLUBLE IN WATER
TARGET BETA-1,3-GLUCAN SYNTHASE
Beta-1,3-glucan synthase catalytic subunit 1 UNIPROT O13428 GSC1
1,3-beta-glucan synthase catalytic subunit FksP UNIPROT Q4WLT4
Formula:
C52H88N10O15
Calculated chemical properties:
MW 1093.32
NB_atoms 77
XLogP -3.31
PSA 360.057
NB_HD 18
NB_HA 25
fsp3 0.75
Lipinski(0=no;1=yes) 0
NB_atoms 77
XLogP -3.31
PSA 360.057
NB_HD 18
NB_HA 25
fsp3 0.75
Lipinski(0=no;1=yes) 0
FDA
NDA 021227 (pdf not found) INN (CASPOFUNGIN ACETATE) CANCIDAS (MERCK) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 206110 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2016
NDA 207092 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (GLAND) APPROVAL= AP YEAR= 2017
NDA 207650 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 200833 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (HENGRUI PHARMA) APPROVAL= AP YEAR= 2018
NDA 205923 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (XELLIA PHARMS APS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209489 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (CIPLA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 211263 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (AREVA PHARMS) APPROVAL= AP YEAR= 2021
NDA 216506 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (HANGZHOU ZHONGMEI) APPROVAL= AP YEAR= 2025
NDA 021227 (pdf not found) INN (CASPOFUNGIN ACETATE) CANCIDAS (MERCK) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 206110 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2016
NDA 207092 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (GLAND) APPROVAL= AP YEAR= 2017
NDA 207650 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 200833 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (HENGRUI PHARMA) APPROVAL= AP YEAR= 2018
NDA 205923 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (XELLIA PHARMS APS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209489 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (CIPLA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 211263 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (AREVA PHARMS) APPROVAL= AP YEAR= 2021
NDA 216506 (pdf not found) INN (CASPOFUNGIN ACETATE) CASPOFUNGIN ACETATE (HANGZHOU ZHONGMEI) APPROVAL= AP YEAR= 2025