e-Drug3D

1290

cas 357-70-0

CLASS

NERVOUS SYSTEM
ALZHEIMER S DISEASE (AD)
ALKALOID
CHOLINESTERASE INHIBITORS

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT
VD 175 LITER
Cl 18 LITER / HOUR
PPB 18 PERCENT
t1/2 7 HOUR

TARGET CHOLINESTERASE

PDB
1QTI (ACETYLCHOLINESTERASE (E.C.3.1.1.7))

Ligand code = GNT (link to the list of PDB complexes)

Download experimental 3D coordinates of GNT with added hydrogens

MW 287.35
NB_atoms 21
XLogP 1.85
PSA 47.995
NB_HD 1
NB_HA 4
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 021169 (label) INN (GALANTAMINE HYDROBROMIDE) RAZADYNE (JANSSEN PHARMS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 021224 (label) INN (GALANTAMINE HYDROBROMIDE) RAZADYNE (JANSSEN PHARMS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 021615 (label) INN (GALANTAMINE HYDROBROMIDE) RAZADYNE ER (JANSSEN PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077588 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (RANBAXY) APPROVAL= TA YEAR= 2007
NDA 077592 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (SUN PHARM INDS) APPROVAL= TA YEAR= 2007
NDA 077767 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (WATSON LABS) APPROVAL= TA YEAR= 2007
NDA 078495 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (RANBAXY) APPROVAL= TA YEAR= 2007 OBSOLETE
NDA 077593 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (SENORES PHARMS) APPROVAL= AP YEAR= 2008
NDA 077603 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 077605 (label) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (BARR) APPROVAL= AP YEAR= 2008
NDA 078189 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (BARR) APPROVAL= AP YEAR= 2008
NDA 079028 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (WATSON LABS) APPROVAL= AP YEAR= 2008
NDA 077585 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077587 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077589 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 077590 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (MYLAN) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077604 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (YABAO PHARM) APPROVAL= AP YEAR= 2009
NDA 077608 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (HIKMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078185 (label) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (HIKMA) APPROVAL= AP YEAR= 2009
NDA 078484 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (IMPAX LABS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077781 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (APOTEX INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 078898 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2011
NDA 090178 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (SUN PHARM) APPROVAL= AP YEAR= 2011
NDA 090900 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090957 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2011
NDA 204895 (pdf not found) INN (GALANTAMINE HYDROBROMIDE) GALANTAMINE HYDROBROMIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016