e-Drug3D

1286

FROVATRIPTAN

INN
FROVATRIPTAN

cas 158747-02-5

CLASS

NERVOUS SYSTEM
ANTIMIGRAINE
SEROTONIN AGONISTS
VASOCONSTRICTOR AGENTS

ROUTE (list)

ORAL

ATC code

N02CC07

PK parameters

F 25 PERCENT
VD 234 LITER (65 KILOGRAM)
Cl 10.5 LITER / HOUR
PPB 15 PERCENT
t1/2 26 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET 5-HYDROXYTRYPTAMINE 1D RECEPTOR
5-HYDROXYTRYPTAMINE 1B RECEPTOR

DrugCentral

5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B

5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D

Download SDF file

(6R)-6-methylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide

Formula:
C14H17N3O

Calculated chemical properties:

MW 243.31
NB_atoms 18
XLogP 1.34
PSA 67.922
NB_HD 4
NB_HA 4
fsp3 0.36
Lipinski(0=no;1=yes) 1

FDA
NDA 021006 (label) INN (FROVATRIPTAN SUCCINATE) FROVA (ENDO OPERATIONS) APPROVAL= AP YEAR= 2001 NEWMOLECULARENTITY
NDA 202931 (pdf not found) INN (FROVATRIPTAN SUCCINATE) FROVATRIPTAN SUCCINATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 204730 (pdf not found) INN (FROVATRIPTAN SUCCINATE) FROVATRIPTAN SUCCINATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2016
NDA 211292 (pdf not found) INN (FROVATRIPTAN SUCCINATE) FROVATRIPTAN SUCCINATE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2018
NDA 213891 (pdf not found) INN (FROVATRIPTAN SUCCINATE) FROVATRIPTAN SUCCINATE (RENATA) APPROVAL= AP YEAR= 2022
NDA 216998 (pdf not found) INN (FROVATRIPTAN SUCCINATE) FROVATRIPTAN SUCCINATE (LEADING) APPROVAL= AP YEAR= 2025