e-Drug3D

1285

ALMOTRIPTAN

INN
ALMOTRIPTAN

cas 154323-57-6

CLASS

NERVOUS SYSTEM
ANTIMIGRAINE
ANTI-INFLAMMATORY AGENTS
SELECTIVE SEROTONIN AGONISTS
VASOCONSTRICTOR AGENTS

ROUTE (list)

ORAL

ATC code

N02CC05

PK parameters

F 70 PERCENT
VD 190 LITER
Cl 37.6 LITER / HOUR (EQN)
PPB 35 PERCENT
t1/2 3.5 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET 5-HYDROXYTRYPTAMINE 1D RECEPTOR
5-HYDROXYTRYPTAMINE 1B RECEPTOR
5-HYDROXYTRYPTAMINE 1F RECEPTOR

DrugCentral

5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B

5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D

Download SDF file

N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine

Formula:
C17H25N3O2S

Calculated chemical properties:

MW 335.47
NB_atoms 23
XLogP 2.20
PSA 58.171
NB_HD 1
NB_HA 5
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 021001 (pdf not found) INN (ALMOTRIPTAN MALATE) AXERT (JANSSEN PHARMS) APPROVAL= AP YEAR= 2001 NEWMOLECULARENTITY DISCONTINUED
NDA 078027 (pdf not found) INN (ALMOTRIPTAN MALATE) ALMOTRIPTAN MALATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2015
NDA 205171 (pdf not found) INN (ALMOTRIPTAN MALATE) ALMOTRIPTAN MALATE (MYLAN) APPROVAL= AP YEAR= 2015
NDA 205523 (pdf not found) INN (ALMOTRIPTAN MALATE) ALMOTRIPTAN MALATE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2016