e-Drug3D

1284

RAPACURONIUM

DISCONTINUED

INN
RAPACURONIUM

(has an active metabolite)

cas 465499-11-0

CLASS

NEUROMUSCULAR BLOCKER
MUSCLE RELAXANT
ANESTHETIC
NEUROMUSCULAR NONDEPOLARIZING AGENTS

ROUTE (list)

INJECTION

ATC code

PK parameters

VD 18.9 LITER (65 KILOGRAM)
Cl 25.3 LITER / HOUR (65 KILOGRAM)
PPB 69 PERCENT
t1/2 2.3 HOUR

Target

TARGET CHOLINERGIC RECEPTOR

DrugCentral

Muscle-type nicotinic acetylcholine receptor UNIPROT P02708 CHRNA1

Download SDF file

[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2-piperidin-1-yl-16-(1-prop-2-enylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate bromide

Formula:
C37H61N2O4

Calculated chemical properties:

MW 597.88
NB_atoms 43
XLogP 6.91
PSA 44.4
NB_HD 0
NB_HA 5
fsp3 0.89
Lipinski(0=no;1=yes) 0

FDA
NDA 020984 (pdf not found) INN (RAPACURONIUM BROMIDE) RAPLON (ORGANON USA INC) APPROVAL= AP YEAR= 1999 NEWMOLECULARENTITY DISCONTINUED