e-Drug3D

1283

cas 136470-78-5

CLASS

ANTIINFECTIVES
ANTI-HIV
ANTIVIRAL
NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

ROUTE (list)

ORAL

PK parameters

F 83 PERCENT
VD 55.9 LITER (65 KILOGRAM)
Cl 52 LITER / HOUR (65 KILOGRAM)
PPB 50 PERCENT (INDEPENDENT OF CONCENTRATION)
t1/2 1.54 HOUR

TARGET GLUCURONOSYLTRANSFERASE
ALCOHOL DEHYDROGENASE
GAG-POL POLYPROTEIN

PDB
5U98 (THE CRYSTAL STRUCTURE OF A SELF-PEPTIDE COMPLEXED TO ABACAVIR AND HLA-B*57:01)

Ligand code = 1KX (link to the list of PDB complexes)

Download experimental 3D coordinates of 1KX with added hydrogens

MW 286.34
NB_atoms 21
XLogP 1.09
PSA 93.152
NB_HD 4
NB_HA 7
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 020977 (label) INN (ABACAVIR SULFATE) ZIAGEN (VIIV HLTHCARE) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 020978 (label) INN (ABACAVIR SULFATE) ZIAGEN (VIIV HLTHCARE) APPROVAL= AP YEAR= 1998
NDA 021205 (label) INN (ABACAVIR SULFATE ; LAMIVUDINE ; ZIDOVUDINE) TRIZIVIR (VIIV HLTHCARE) APPROVAL= AP YEAR= 2000
NDA 021652 (label) INN (ABACAVIR SULFATE ; LAMIVUDINE) EPZICOM (VIIV HLTHCARE) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021944 (pdf not found) INN (LAMIVUDINE ; ZIDOVUDINE ; ABACAVIR) LAMIVUDINE; ZIDOVUDINE; ABACAVIR (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2006
NDA 078742 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (MATRIX LABS) APPROVAL= TA YEAR= 2007
NDA 022293 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (AUROBINDO PHARMA) APPROVAL= TA YEAR= 2008
NDA 022295 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE; LAMIVUDINE (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2008
NDA 090309 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE ; ZIDOVUDINE) ABACAVIR SULFATE, LAMIVUDINE AND ZIDOVUDINE (MYLAN PHARMA) APPROVAL= TA YEAR= 2009
NDA 090519 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE; LAMIVUDINE (MATRIX LABS LTD) APPROVAL= TA YEAR= 2009
NDA 200733 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (MATRIX LABS LTD) APPROVAL= TA YEAR= 2010
NDA 022547 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (CIPLA LIMITED) APPROVAL= TA YEAR= 2011
NDA 078348 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (CIPLA LIMITED) APPROVAL= TA YEAR= 2011
NDA 202007 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE; LAMIVUDINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2011
NDA 077844 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 091294 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2012
NDA 202381 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE; LAMIVUDINE (MYLAN LABS) APPROVAL= TA YEAR= 2012
NDA 201570 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (APOTEX INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 091560 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2013
NDA 202912 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE ; ZIDOVUDINE) ABACAVIR SULFATE, LAMIVUDINE AND ZIDOVUDINE (LUPIN LTD) APPROVAL= AP YEAR= 2013
NDA 204311 (label) INN (ABACAVIR ; LAMIVUDINE) ABACAVIR AND LAMIVUDINE (MYLAN LABS LTD) APPROVAL= TA YEAR= 2014
NDA 204915 (pdf not found) INN (ABACAVIR ; LAMIVUDINE) ABACAVIR AND LAMIVUDINE (MYLAN LABS LTD) APPROVAL= TA YEAR= 2014
NDA 205412 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE; LAMIVUDINE (HETERO LABS LTD V) APPROVAL= TA YEAR= 2014
NDA 205551 (label) INN (ABACAVIR SULFATE ; DOLUTEGRAVIR SODIUM ; LAMIVUDINE) TRIUMEQ (VIIV HLTHCARE) APPROVAL= AP YEAR= 2014
NDA 207369 (pdf not found) INN (ABACAVIR ; LAMIVUDINE) ABACAVIR; LAMIVUDINE (HETERO LABS LTD V) APPROVAL= TA YEAR= 2015
NDA 079246 (label) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE AND LAMIVUDINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 091050 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (CHARTWELL RX) APPROVAL= AP YEAR= 2016
NDA 201107 (label) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2016
NDA 204004 (pdf not found) INN (ABACAVIR ; LAMIVUDINE) EPZICOM (MYLAN PHARMS INC) APPROVAL= TA YEAR= 2016
NDA 078119 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (CIPLA) APPROVAL= AP YEAR= 2017
NDA 091144 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE AND LAMIVUDINE (CIPLA) APPROVAL= AP YEAR= 2017
NDA 204990 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE AND LAMIVUDINE (CHARTWELL RX) APPROVAL= AP YEAR= 2017
NDA 206151 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE AND LAMIVUDINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208775 (pdf not found) INN (ABACAVIR ; LAMIVUDINE) ABACAVIR AND LAMIVUDINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2017
NDA 077950 (pdf not found) INN (ABACAVIR SULFATE) ABACAVIR SULFATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018
NDA 090159 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE AND LAMIVUDINE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018
NDA 208990 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE AND LAMIVUDINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 215413 (label) INN (ABACAVIR SULFATE ; DOLUTEGRAVIR SODIUM ; LAMIVUDINE) TRIUMEQ PD (VIIV HLTHCARE) APPROVAL= AP YEAR= 2022
NDA 216223 (pdf not found) INN (ABACAVIR ; DOLUTEGRAVIR ; LAMIVUDINE) ABACAVIR; DOLUTEGRAVIR; LAMIVUDINE (LAURUS LABS LTD) APPROVAL= TA YEAR= 2022
NDA 216332 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE AND LAMIVUDINE (LAURUS) APPROVAL= AP YEAR= 2022
NDA 217070 (pdf not found) INN (ABACAVIR ; DOLUTEGRAVIR ; LAMIVUDINE) ABACAVIR; DOLUTEGRAVIR; LAMIVUDINE (AUROBINDO PHARMA USA) APPROVAL= TA YEAR= 2023
NDA 212181 (pdf not found) INN (ABACAVIR ; DOLUTEGRAVIR ; LAMIVUDINE) ABACAVIR || DOLUTEGRAVIR || LAMIVUDINE (EMCURE PHARMS LTD) APPROVAL= TA YEAR= 2024
NDA 212663 (pdf not found) INN (ABACAVIR SULFATE ; LAMIVUDINE) ABACAVIR SULFATE AND LAMIVUDINE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 218383 (pdf not found) INN (ABACAVIR ; DOLUTEGRAVIR ; LAMIVUDINE) ABACAVIR; DOLUTEGRAVIR; LAMIVUDINE (LUPIN LTD) APPROVAL= TA YEAR= 2024
NDA 210391 (pdf not found) INN (ABACAVIR ; DOLUTEGRAVIR ; LAMIVUDINE) ABACAVIR, DOLUTEGRAVIR, LAMIVUDINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2025
NDA 210811 (pdf not found) INN (ABACAVIR ; DOLUTEGRAVIR ; LAMIVUDINE) DOLUTEGRAVIR SODIUM AND ABACAVIR SULFATE AND LAMIVUDINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2025