e-Drug3D

1280

cas 113665-84-2

CLASS

BLOOD
ANTICOAGULANT
PLATELET AGGREGATION INHIBITOR
ANTITHROMBOTIC
ANTIANGINAL
FIBRINOLYTIC AGENTS
TREATMENT OF ACUTE CORONARY SYNDROME, MYOCARDIAL INFARCTION, STROKE
ACTION THROUGH IRREVERSIBLE BINDING OF ITS METABOLITE

ROUTE (list)

ORAL

PK parameters

F 50 PERCENT
Tmax 0.75 HOUR
PPB 98 PERCENT
t1/2 6 HOUR

TARGET P2Y PURINOCEPTOR 12

PDB
3ME6 (CRYSTAL STRUCTURE OF CYTOCHROME 2B4 IN COMPLEX WITH THE ANTI-PLATELET DRUG CLOPIDOGREL)

Ligand code = CGE (link to the list of PDB complexes)

Download experimental 3D coordinates of CGE with added hydrogens

MW 321.82
NB_atoms 21
XLogP 3.67
PSA 26.447
NB_HD 0
NB_HA 3
fsp3 0.31
Lipinski(0=no;1=yes) 1

FDA
NDA 020839 (pdf not found) INN (CLOPIDOGREL BISULFATE) PLAVIX (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1997
NDA 076273 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (DR REDDYS) APPROVAL= AP YEAR= 2008
NDA 076274 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (APOTEX INC) APPROVAL= AP YEAR= 2012
NDA 077665 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (RISING) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078004 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (ACME LABS) APPROVAL= AP YEAR= 2012
NDA 090844 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (TORRENT PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 091023 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2012
NDA 090494 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (SUN PHARM) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 076999 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (TEVA) APPROVAL= AP YEAR= 2012
NDA 090540 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 090625 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (ANI PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 091216 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (ANI PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201686 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202266 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (CHARTWELL RX) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078133 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 090307 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202925 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202928 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 203751 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2014
NDA 204165 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2014
NDA 204359 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (RISING) APPROVAL= AP YEAR= 2017
NDA 206376 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (PRINSTON INC) APPROVAL= AP YEAR= 2018
NDA 213351 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (POLYGEN PHARMS) APPROVAL= AP YEAR= 2020
NDA 203632 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2023
NDA 205345 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2023
NDA 215388 (pdf not found) INN (CLOPIDOGREL BISULFATE) CLOPIDOGREL BISULFATE (MSN) APPROVAL= AP YEAR= 2024