e-Drug3D

1273

EMEDASTINE

DISCONTINUED

INN
EMEDASTINE

cas 87233-61-2

CLASS

ALLERGIC CONJUNCTIVITIS
SENSORY
ANTAGONIST
ANTIHISTAMINE
ANTIALLERGIC
H2 (KI=49 NANOMOLAR)
H3 (KI=12 NANOMOLAR)
DEVOID OF EFFECTS ON ADRENERGIC, DOPAMINERGIC AND SEROTONIN RECEPTORS

ROUTE (list)

OPHTHALMIC

ATC code

S01GX06

PK parameters

t1/2 3.5 HOUR

Solubility

WATER SOLUBLE FINE POWDER

Target

TARGET HISTAMINE H1 RECEPTOR (KI=1.3 NANOMOLAR)

DrugCentral

Histamine H1 receptor UNIPROT P35367 HRH1

Download SDF file

1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole

Formula:
C17H26N4O

Calculated chemical properties:

MW 302.42
NB_atoms 22
XLogP 2.21
PSA 34.756
NB_HD 0
NB_HA 5
fsp3 0.59
Lipinski(0=no;1=yes) 1

FDA
NDA 020706 (pdf not found) INN (EMEDASTINE DIFUMARATE) EMADINE (NOVARTIS) APPROVAL= AP YEAR= 1997 DISCONTINUED