e-Drug3D

1270

cas 104632-26-0

CLASS

NERVOUS SYSTEM
NONERGOT DOPAMINE RECEPTOR AGONIST
RESTLESS LEGS SYNDROME (RLS)
ANTIPSYCHOTIC
ANTIPARKINSONIAN
ANTIGLAUCOMA
ANTIDYSKINETICS
DOPAMINE D2 RECEPTOR AGONIST
DOPAMINE D4 RECEPTOR AGONIST

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT
VD 500 LITER
Cl 43.3 LITER / HOUR (EQN)
PPB 15 PERCENT
t1/2 8 HOUR

TARGET D3 DOPAMINE RECEPTOR

PDB
7CMU (DOPAMINE RECEPTOR D3R-GI-PRAMIPEXOLE COMPLEX)

Ligand code = G6L (link to the list of PDB complexes)

Download experimental 3D coordinates of G6L with added hydrogens

MW 211.34
NB_atoms 14
XLogP 1.58
PSA 48.723
NB_HD 3
NB_HA 3
fsp3 0.70
Lipinski(0=no;1=yes) 1

FDA
NDA 020667 (label) INN (PRAMIPEXOLE DIHYDROCHLORIDE) MIRAPEX (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 077724 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 077854 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (NATCO) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022421 (label) INN (PRAMIPEXOLE DIHYDROCHLORIDE) MIRAPEX ER (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022514 (label) INN (PRAMIPEXOLE DIHYDROCHLORIDE) MIRAPEX ER (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2010 NEWAPPLICATION
NDA 078894 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090190 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090764 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (NATCO PHARMA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090781 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2010
NDA 078551 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078920 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2010
NDA 090241 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090865 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (TORRENT PHARMS) APPROVAL= AP YEAR= 2010
NDA 091254 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091450 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (AVIV PHARMA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090151 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (ZENNOVA) APPROVAL= AP YEAR= 2012
NDA 202164 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202633 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 091683 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202206 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202353 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2014
NDA 202702 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2014
NDA 203855 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2014
NDA 203354 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2015
NDA 201963 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2016
NDA 206156 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2016
NDA 203615 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2016
NDA 202891 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 207011 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 211088 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2018
NDA 204518 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 212797 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (XIAMEN LP PHARM CO) APPROVAL= AP YEAR= 2021
NDA 213444 (pdf not found) INN (PRAMIPEXOLE DIHYDROCHLORIDE) PRAMIPEXOLE DIHYDROCHLORIDE (NOVAST LABS) APPROVAL= AP YEAR= 2022