e-Drug3D
1261
CYSTEAMINE
INN
CYSTEAMINE
cas 60-23-1
CLASS
METABOLISM
NEPHROPATHIC CYSTINOSIS THERAPY
REACTANT
CYSTEAMINE IS AN AMINOTHIOL THAT PARTICIPATES WITHIN LYSOSOMES IN A THIOL-DISULFIDE INTERCHANGE REACTION CONVERTING CYSTINE IN TO CYSTEINE AND CYSTEINE-CYSTEAMINE MIXED DISULFIDE, BOTH OF WHICH CAN EXIT THE LYSOSOME IN PATIENTS WITH CYSTINOSIS
ROUTE (list)
ORAL OPHTHALMIC
PK parameters
VD 156 LITER
Cl 72 LITER / HOUR
PPB 52 PERCENT
t1/2 1.5 HOUR (EQN)
Solubility
HIGHLY WATER SOLUBLE
-
PDB
4CG4 (CRYSTAL STRUCTURE OF THE CHS-B30.2 DOMAINS OF TRIM20)
Ligand code = DHL (link to the list of PDB complexes)
Download experimental 3D coordinates of DHL with added hydrogens
Unknown
Formula:
C2H7NS
Calculated chemical properties:
MW 77.16
NB_atoms 4
XLogP -0.13
PSA 25.246
NB_HD 2
NB_HA 1
fsp3 1.00
Lipinski(0=no;1=yes) 1
NB_atoms 4
XLogP -0.13
PSA 25.246
NB_HD 2
NB_HA 1
fsp3 1.00
Lipinski(0=no;1=yes) 1
FDA
NDA 020392 (label) INN (CYSTEAMINE BITARTRATE) CYSTAGON (MYLAN) APPROVAL= AP YEAR= 1994 NEWMOLECULARENTITY
NDA 200740 (label) INN (CYSTEAMINE HYDROCHLORIDE) CYSTARAN (LEADIANT BIOSCI INC) APPROVAL= AP YEAR= 2012
NDA 203389 (label) INN (CYSTEAMINE BITARTRATE) PROCYSBI (HORIZON) APPROVAL= AP YEAR= 2013
NDA 213491 (label) INN (CYSTEAMINE BITARTRATE) PROCYSBI (HORIZON) APPROVAL= AP YEAR= 2020
NDA 211302 (label) INN (CYSTEAMINE HYDROCHLORIDE) CYSTADROPS (RECORDATI RARE) APPROVAL= AP YEAR= 2020
NDA 020392 (label) INN (CYSTEAMINE BITARTRATE) CYSTAGON (MYLAN) APPROVAL= AP YEAR= 1994 NEWMOLECULARENTITY
NDA 200740 (label) INN (CYSTEAMINE HYDROCHLORIDE) CYSTARAN (LEADIANT BIOSCI INC) APPROVAL= AP YEAR= 2012
NDA 203389 (label) INN (CYSTEAMINE BITARTRATE) PROCYSBI (HORIZON) APPROVAL= AP YEAR= 2013
NDA 213491 (label) INN (CYSTEAMINE BITARTRATE) PROCYSBI (HORIZON) APPROVAL= AP YEAR= 2020
NDA 211302 (label) INN (CYSTEAMINE HYDROCHLORIDE) CYSTADROPS (RECORDATI RARE) APPROVAL= AP YEAR= 2020