e-Drug3D

1259

cas 143558-00-3

CLASS

MUSCULO-SKELETAL SYSTEM
NEUROMUSCULAR NONDEPOLARIZING AGENTS
BLOCKER
SKELETAL MUSCLE RELAXANTS
ANESTHESIA
CHOLINERGIC RECEPTOR

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

VD 16.2 LITER (65 KILOGRAM)
Cl 16.2 LITER / HOUR (65 KILOGRAM)
PPB 30 PERCENT
t1/2 1.4 HOUR

TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M2
NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2

PDB
8F2S (CRYO-EM STRUCTURE OF TORPEDO NICOTINIC ACETYLCHOLINE RECEPTOR IN COMPLEX WITH ROCURONIUM, PORE-BLOCKED STATE)

Ligand code = RBR (link to the list of PDB complexes)

Download experimental 3D coordinates of RBR with added hydrogens

MW 529.76
NB_atoms 38
XLogP 4.41
PSA 52.093
NB_HD 1
NB_HA 5
fsp3 0.91
Lipinski(0=no;1=yes) 0

FDA
NDA 020214 (label) INN (ROCURONIUM BROMIDE) ZEMURON (ORGANON USA INC) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 078519 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (HOSPIRA) APPROVAL= AP YEAR= 2008
NDA 078651 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2008
NDA 078717 (label) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (TEVA PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 079195 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (SANDOZ) APPROVAL= AP YEAR= 2008
NDA 079199 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2008
NDA 091458 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2010
NDA 091115 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (TAMARANG) APPROVAL= AP YEAR= 2012
NDA 204679 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (WEST WARD PHARM CORP) APPROVAL= AP YEAR= 2017
NDA 206206 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2017
NDA 205656 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (GLAND) APPROVAL= AP YEAR= 2018
NDA 210437 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (PIRAMAL CRITICAL) APPROVAL= AP YEAR= 2019
NDA 212668 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 213453 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (MEITHEAL) APPROVAL= AP YEAR= 2023
NDA 216234 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (CAPLIN) APPROVAL= AP YEAR= 2023
NDA 217034 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (HIKMA) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 204918 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 215684 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (SHANDONG) APPROVAL= AP YEAR= 2024
NDA 217092 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (STERISCIENCE) APPROVAL= AP YEAR= 2024
NDA 217472 (label) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2025
NDA 219674 (pdf not found) INN (ROCURONIUM BROMIDE) ROCURONIUM BROMIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2025