e-Drug3D

1256

cas 57248-88-1

CLASS

MUSCOLO-SKELETAL SYSTEM
ANTI-INFLAMMATORY AGENTS
ANTINEOPLASTIC AGENTS
BISPHOSPHONATES
BONE DENSITY CONSERVATION AGENTS
INHIBITOR

ROUTE (list)

INJECTION

PK parameters

F 54 PERCENT
Cl 6.4 LITER / HOUR
PPB 54 PERCENT
t1/2 28 HOUR

TARGET FARNESYL PYROPHOSPHATE SYNTHASE

PDB
5ERO (CRYSTAL STRUCTURE OF ELONGATION DOMAIN OF PHOMOPSIS AMYGDALI FUSICOCCADIENE SYNTHASE COMPLEXED WITH COBALT IONS AND PAMIDRONATE)

Ligand code = 210 (link to the list of PDB complexes)

Download experimental 3D coordinates of 210 with added hydrogens

MW 231.04
NB_atoms 13
XLogP -4.19
PSA 154.664
NB_HD 3
NB_HA 8
fsp3 1.00
Lipinski(0=no;1=yes) 0

FDA
NDA 020036 (pdf not found) INN (PAMIDRONATE DISODIUM) AREDIA (NOVARTIS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 020927 (pdf not found) INN (PAMIDRONATE DISODIUM) AREDIA (NOVARTIS) APPROVAL= AP YEAR= 1998 NEWAPPLICATION
NDA 075290 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (HIKMA) APPROVAL= AP YEAR= 2001
NDA 021113 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (HIKMA) APPROVAL= AP YEAR= 2002
NDA 075594 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (AESGEN) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075773 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075841 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (HOSPIRA) APPROVAL= AP YEAR= 2002
NDA 076153 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076207 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 078156 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (DR REDDYS) APPROVAL= AP YEAR= 2008
NDA 078942 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (AM REGENT) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 077433 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (AREVA PHARMS) APPROVAL= AP YEAR= 2008
NDA 077703 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (SUN PHARMA GLOBAL) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078373 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2008
NDA 078520 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (MYLAN LABS LTD) APPROVAL= AP YEAR= 2008
NDA 078300 (pdf not found) INN (PAMIDRONATE DISODIUM) PAMIDRONATE DISODIUM (MN PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED