e-Drug3D

1255

FENOLDOPAM

DISCONTINUED

INN
FENOLDOPAM

cas 67227-56-9

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
SHORT-TERM MANAGEMENT OF SEVERE HYPERTENSION
DOPAMINE AGONISTS
VASODILATOR AGENTS
BINDS MODERATLY TO ALPHA-2 ADRENERGIC RECEPTOR
R-ISOMER HAS 250-FOLD HIGHER AFFINITY THAN S-ISOMER

ROUTE (list)

INJECTION

ATC code

C01CA19

PK parameters

t1/2 0.083 HOUR

Solubility

SPARINGLY SOLUBLE IN WATER

Target

TARGET D1 DOPAMINE RECEPTOR

PDB
7CKW (CRYO-EM STRUCTURE OF FENOLDOPAM BOUND DOPAMINE RECEPTOR DRD1-GS SIGNALING COMPLEX)

Ligand code = G3C (link to the list of PDB complexes)

Download experimental 3D coordinates of G3C with added hydrogens

DrugCentral

D(1A) dopamine receptor UNIPROT P21728 DRD1

Download SDF file

6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol

Formula:
C16H16ClNO3

Calculated chemical properties:

MW 305.75
NB_atoms 21
XLogP 2.73
PSA 76.462
NB_HD 4
NB_HA 4
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 019922 (label) INN (FENOLDOPAM MESYLATE) CORLOPAM (HOSPIRA) APPROVAL= AP YEAR= 1997 NEWMOLECULARENTITY DISCONTINUED
NDA 076656 (pdf not found) INN (FENOLDOPAM MESYLATE) FENOLDOPAM MESYLATE (LUITPOLD) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076582 (pdf not found) INN (FENOLDOPAM MESYLATE) FENOLDOPAM MESYLATE (HIKMA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077155 (pdf not found) INN (FENOLDOPAM MESYLATE) FENOLDOPAM MESYLATE (SANDOZ) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077826 (pdf not found) INN (FENOLDOPAM MESYLATE) FENOLDOPAM MESYLATE (TEVA PARENTERAL) APPROVAL= AP YEAR= 2007 DISCONTINUED