e-Drug3D

1253

NAFARELIN

INN
NAFARELIN

cas 76932-56-4

CLASS

HORMONES
TREATMENT OF CENTRAL PRECOCIOUS PUBERTY (CPP)
GONADOTROPIN-RELEASING HORMONE AGONIST

ROUTE (list)

NASAL

ATC code

H01CA02

PK parameters

F 2.8 PERCENT
Tmax 0.4 HOUR
PPB 80 PERCENT
t1/2 3 HOUR

Target

TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR
GONADOTROPIN-RELEASING HORMONE II RECEPTOR

DrugCentral

Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR

Download SDF file

N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Formula:
C66H83N17O13

Calculated chemical properties:

MW 1323.50
NB_atoms 96
XLogP -3.23
PSA 433.125
NB_HD 20
NB_HA 29
fsp3 0.41
Lipinski(0=no;1=yes) 0

FDA
NDA 019886 (label) INN (NAFARELIN ACETATE) SYNAREL (PFIZER) APPROVAL= AP YEAR= 1990