e-Drug3D

1252

GOSERELIN

INN
GOSERELIN

cas 65807-02-5

CLASS

ANTINEOPLASTIC
PROSTATE CANCER (THERAPEUTIC)
GONADOTROPIN RELEASING HORMONE (GNRH) AGONIST
INHIBITS PITUITARY GONADOTROPIN SECRETION

ROUTE (list)

IMPLANTATION

ATC code

L02AE03

PK parameters

VD 20.3 LITER
Cl 9.78 LITER / HOUR
PPB 27.3 PERCENT
t1/2 1.4 HOUR (EQN)

Solubility

SOLUBLE IN WATER

Target

TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR

DrugCentral

Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR

Download SDF file

N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Formula:
C59H84N18O14

Calculated chemical properties:

MW 1270.45
NB_atoms 91
XLogP -4.72
PSA 457.333
NB_HD 21
NB_HA 31
fsp3 0.51
Lipinski(0=no;1=yes) 0

FDA
NDA 019726 (label) INN (GOSERELIN ACETATE) ZOLADEX (TERSERA) APPROVAL= AP YEAR= 1989
NDA 020578 (label) INN (GOSERELIN ACETATE) ZOLADEX (TERSERA) APPROVAL= AP YEAR= 1996