e-Drug3D

1247

cas 78415-72-2

CLASS

CARDIOVASCULAR
POSITIVE INOTROPE
CARDIOTONIC
PHOSPHODIESTERASE INHIBITORS
PLATELET AGGREGATION INHIBITORS
VASODILATOR AGENTS

ROUTE (list)

INJECTION

PK parameters

VD 24.7 LITER (65 KILOGRAM)
Cl 8.4 LITER / HOUR (65 KILOGRAM)
PPB 70 PERCENT
t1/2 2.3 HOUR

TARGET CAMP 3',5'-CYCLIC PHOSPHODIESTERASE 3

PDB
1TLM (STRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX)

Ligand code = MIL (link to the list of PDB complexes)

Download experimental 3D coordinates of MIL with added hydrogens

MW 211.22
NB_atoms 16
XLogP 1.62
PSA 58.728
NB_HD 1
NB_HA 4
fsp3 0.08
Lipinski(0=no;1=yes) 1

FDA
NDA 019436 (label) INN (MILRINONE LACTATE) PRIMACOR (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1987 NEWMOLECULARENTITY DISCONTINUED
NDA 020343 (pdf not found) INN (MILRINONE LACTATE) PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 075510 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER (HIKMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075530 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (HIKMA) APPROVAL= AP YEAR= 2002
NDA 075660 (label) INN (MILRINONE LACTATE) MILRINONE LACTATE (HIKMA) APPROVAL= AP YEAR= 2002
NDA 075830 (label) INN (MILRINONE LACTATE) MILRINONE LACTATE (HOSPIRA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075834 (label) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER (BAXTER HLTHCARE) APPROVAL= AP YEAR= 2002
NDA 075852 (label) INN (MILRINONE LACTATE) MILRINONE LACTATE (HIKMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075884 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (HOSPIRA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075885 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER (HOSPIRA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075936 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2002
NDA 076013 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (INTL MEDICATED) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076259 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER (BAXTER HLTHCARE) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076428 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076414 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER (B BRAUN) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076427 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2004
NDA 077151 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER (WOODWARD) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077190 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (GLAND PHARMA LTD) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 078113 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER (HIKMA) APPROVAL= AP YEAR= 2008
NDA 090038 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN PLASTIC CONTAINER (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2010
NDA 077966 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2010
NDA 203280 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (HOSPIRA) APPROVAL= AP YEAR= 2014
NDA 211671 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (MEITHEAL) APPROVAL= AP YEAR= 2020
NDA 213585 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER (GLAND) APPROVAL= AP YEAR= 2020
NDA 209666 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE IN DEXTROSE 5% (EUGIA PHARMA) APPROVAL= AP YEAR= 2020
NDA 214380 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (CAPLIN) APPROVAL= AP YEAR= 2021
NDA 216373 (pdf not found) INN (MILRINONE LACTATE) MILRINONE LACTATE (SHANDONG) APPROVAL= AP YEAR= 2023