e-Drug3D
1245
BUTOCONAZOLE
INN
BUTOCONAZOLE
cas 64872-76-0
CLASS
GENITO
ANTIFUNGAL
INHIBITION OF STEROID SYNTHESIS (INHIBITION OF CONVERSION OF LANOSTEROL TO ERGOSTEROL)
ROUTE (list)
VAGINAL
ATC code
G01AF15
PK parameters
F 2 PERCENT
Tmax 18 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE
Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11
Formula:
C19H17Cl3N2S
Calculated chemical properties:
MW 411.77
NB_atoms 25
XLogP 6.64
PSA 13.678
NB_HD 0
NB_HA 2
fsp3 0.21
Lipinski(0=no;1=yes) 0
NB_atoms 25
XLogP 6.64
PSA 13.678
NB_HD 0
NB_HA 2
fsp3 0.21
Lipinski(0=no;1=yes) 0
FDA
NDA 019215 (pdf not found) INN (BUTOCONAZOLE NITRATE) FEMSTAT (ROCHE PALO) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 019359 (pdf not found) INN (BUTOCONAZOLE NITRATE) FEMSTAT (ROCHE PALO) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 020421 (pdf not found) INN (BUTOCONAZOLE NITRATE) FEMSTAT 3 (BAYER) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 019881 (label) INN (BUTOCONAZOLE NITRATE) BUTOCONAZOLE NITRATE (PADAGIS US) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 200923 (pdf not found) INN (BUTOCONAZOLE NITRATE) GYNAZOLE-1 (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2012
NDA 019215 (pdf not found) INN (BUTOCONAZOLE NITRATE) FEMSTAT (ROCHE PALO) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 019359 (pdf not found) INN (BUTOCONAZOLE NITRATE) FEMSTAT (ROCHE PALO) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 020421 (pdf not found) INN (BUTOCONAZOLE NITRATE) FEMSTAT 3 (BAYER) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 019881 (label) INN (BUTOCONAZOLE NITRATE) BUTOCONAZOLE NITRATE (PADAGIS US) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 200923 (pdf not found) INN (BUTOCONAZOLE NITRATE) GYNAZOLE-1 (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2012