e-Drug3D
1223
MAFENIDE
INN
MAFENIDE
cas 138-39-6
CLASS
DERMATOLOGICALS
ANTIBACTERIAL
SULFONAMIDES
ANTIBIOTIC
ROUTE (list)
TOPICAL
ATC code
D06BA03
PK parameters
Tmax 2 HOUR
Solubility
SOLUBLE IN WATER
TARGET CARBONIC ANHYDRASE (SECONDARY TARGET)
PDB
5JNC (CRYSTAL STRUCTURE FOR THE COMPLEX OF HUMAN CARBONIC ANHYDRASE IV AND 4-AMINOMETHYLBENZENE SULFONAMIDE)
Ligand code = 6LH (link to the list of PDB complexes)
Download experimental 3D coordinates of 6LH with added hydrogens
Dihydropteroate synthase UNIPROT P0AC13 folP
Formula:
C7H10N2O2S
Calculated chemical properties:
MW 186.24
NB_atoms 12
XLogP -0.21
PSA 85.058
NB_HD 4
NB_HA 4
fsp3 0.14
Lipinski(0=no;1=yes) 1
NB_atoms 12
XLogP -0.21
PSA 85.058
NB_HD 4
NB_HA 4
fsp3 0.14
Lipinski(0=no;1=yes) 1
FDA
NDA 016763 (pdf not found) INN (MAFENIDE ACETATE) SULFAMYLON (RISING) APPROVAL= AP YEAR= 1969
NDA 019832 (label) INN (MAFENIDE ACETATE) SULFAMYLON (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 201511 (pdf not found) INN (MAFENIDE ACETATE) MAFENIDE ACETATE (PH HEALTH) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 206716 (pdf not found) INN (MAFENIDE ACETATE) MAFENIDE ACETATE (NOVAST LABS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 016763 (pdf not found) INN (MAFENIDE ACETATE) SULFAMYLON (RISING) APPROVAL= AP YEAR= 1969
NDA 019832 (label) INN (MAFENIDE ACETATE) SULFAMYLON (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 201511 (pdf not found) INN (MAFENIDE ACETATE) MAFENIDE ACETATE (PH HEALTH) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 206716 (pdf not found) INN (MAFENIDE ACETATE) MAFENIDE ACETATE (NOVAST LABS) APPROVAL= AP YEAR= 2017 DISCONTINUED