e-Drug3D

1218

GUANETHIDINE

DISCONTINUED

INN
GUANETHIDINE

cas 55-65-2

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC NEURON BLOCKER
SYMPATHOLYTICS

ROUTE (list)

ORAL

ATC code

C02CC02
S01EX01
C02LF01

PK parameters

t1/2 SEVERAL DAYS

Target

TARGET NITRIC OXIDE SYNTHASE (PMID10889350)

DrugCentral

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

2-[2-(azocan-1-yl)ethyl]guanidine

Formula:
C10H22N4

Calculated chemical properties:

MW 198.32
NB_atoms 14
XLogP 0.53
PSA 61.688
NB_HD 4
NB_HA 4
fsp3 0.90
Lipinski(0=no;1=yes) 1

FDA
NDA 013553 (pdf not found) INN (GUANETHIDINE MONOSULFATE ; HYDROCHLOROTHIAZIDE) ESIMIL (NOVARTIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086113 (pdf not found) INN (GUANETHIDINE MONOSULFATE) GUANETHIDINE MONOSULFATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086114 (pdf not found) INN (GUANETHIDINE MONOSULFATE) GUANETHIDINE MONOSULFATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012329 (pdf not found) INN (GUANETHIDINE MONOSULFATE) ISMELIN (NOVARTIS) APPROVAL= AP YEAR= 1960 DISCONTINUED