e-Drug3D

1215

CYCLIZINE

DISCONTINUED

INN
CYCLIZINE

cas 82-92-8

CLASS

RESPIRATORY
ANTIHISTAMINE
ANTIEMETIC
HISTAMINE H1 RECEPTOR ANTAGONIST
ANTICHOLINERGIC

ROUTE (list)

INJECTION

PK parameters

Target

TARGET HISTAMINE H1 RECEPTOR
MUSCARINIC ACETYLCHOLINE RECEPTOR M3
MUSCARINIC ACETYLCHOLINE RECEPTOR M1
MUSCARINIC ACETYLCHOLINE RECEPTOR M2

Histamine H1 receptor UNIPROT P35367 HRH1

Download SDF file

1-[di(phenyl)methyl]-4-methylpiperazine

Formula:
C18H22N2

Calculated chemical properties:

MW 266.38
NB_atoms 20
XLogP 3.02
PSA 10.008
NB_HD 0
NB_HA 2
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 009495 (pdf not found) INN (CYCLIZINE LACTATE) MAREZINE (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1954 DISCONTINUED