e-Drug3D

1210

PRIMAQUINE

INN
PRIMAQUINE

cas 90-34-6

CLASS

ANTIPARASITIC
ANTIMALARIAL
ANTIPROTOZOAL AGENTS
CAPABLE OF CLEARING THE INTRA-HEPATIC SCHIZONTS AND HYPNOZOITES OF PLASMODIUM VIVAX
PRECIPITATE HAEMOLYSIS IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENT INDIVIDUALS
GAMETOCYTOCIDAL AGENT IN FALCIPARUM MALARIA
INTERFERE WITH THE CELLULAR RESPIRATION OF THE PARASITE BY GENERATING OXYGEN FREE RADICALS AND DEREGULATING THE ELECTRON TRANSPORT

ROUTE (list)

ORAL

ATC code

P01BA03

PK parameters

VD 292 LITER
Cl 37.6 LITER / HOUR
t1/2 5.6 HOUR

Target

PDB
4FGJ (OXIDIZED QUINONE REDUCTASE 2 IN COMPLEX WITH PRIMAQUINE)

Ligand code = 1PQ (link to the list of PDB complexes)

Download experimental 3D coordinates of 1PQ with added hydrogens

DrugCentral

Unknown

Download SDF file

N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine

Formula:
C15H21N3O

Calculated chemical properties:

MW 259.35
NB_atoms 19
XLogP 2.78
PSA 57.923
NB_HD 3
NB_HA 4
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 008316 (label) INN (PRIMAQUINE PHOSPHATE) PRIMAQUINE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1952
NDA 014860 (pdf not found) INN (CHLOROQUINE PHOSPHATE ; PRIMAQUINE PHOSPHATE) ARALEN PHOSPHATE W/ PRIMAQUINE PHOSPHATE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 203924 (pdf not found) INN (PRIMAQUINE PHOSPHATE) PRIMAQUINE PHOSPHATE (ALVOGEN) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 204476 (pdf not found) INN (PRIMAQUINE PHOSPHATE) PRIMAQUINE PHOSPHATE (UNICHEM) APPROVAL= AP YEAR= 2014
NDA 206043 (pdf not found) INN (PRIMAQUINE PHOSPHATE) PRIMAQUINE PHOSPHATE (NOVAST LABS) APPROVAL= AP YEAR= 2016