e-Drug3D
1208
PHENTOLAMINE
INN
PHENTOLAMINE
cas 50-60-2
CLASS
CARDIOVASCULAR
ALPHA ADRENERGIC RECEPTOR ANTAGONIST
ANTIHYPERTENSIVE AGENTS
SYMPATHOLYTICS
REVERSAL OF SOFT-TISSUE ANESTHESIA
ROUTE (list)
INJECTION OPHTHALMIC
PK parameters
F 100 PERCENT
Tmax 0.25 HOUR
t1/2 2.5 HOUR
Solubility
SPARINGLY SOLUBLE IN WATER
TARGET ALPHA ADRENERGIC RECEPTOR
Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A
Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A
Formula:
C17H19N3O
Calculated chemical properties:
MW 281.35
NB_atoms 21
XLogP 2.84
PSA 48.061
NB_HD 2
NB_HA 4
fsp3 0.24
Lipinski(0=no;1=yes) 1
NB_atoms 21
XLogP 2.84
PSA 48.061
NB_HD 2
NB_HA 4
fsp3 0.24
Lipinski(0=no;1=yes) 1
FDA
NDA 008278 (pdf not found) INN (PHENTOLAMINE MESYLATE) REGITINE (NOVARTIS) APPROVAL= AP YEAR= 1952 DISCONTINUED
NDA 040235 (pdf not found) INN (PHENTOLAMINE MESYLATE) PHENTOLAMINE MESYLATE (HIKMA) APPROVAL= AP YEAR= 1998
NDA 022159 (label) INN (PHENTOLAMINE MESYLATE) ORAVERSE (SEPTODONT HOLDING) APPROVAL= AP YEAR= 2008
NDA 207686 (pdf not found) INN (PHENTOLAMINE MESYLATE) PHENTOLAMINE MESYLATE (PRECISION DOSE INC) APPROVAL= AP YEAR= 2017
NDA 217064 (label) INN (PHENTOLAMINE MESYLATE) RYZUMVI (FAMYGEN LIFE SCI) APPROVAL= AP YEAR= 2023
NDA 008278 (pdf not found) INN (PHENTOLAMINE MESYLATE) REGITINE (NOVARTIS) APPROVAL= AP YEAR= 1952 DISCONTINUED
NDA 040235 (pdf not found) INN (PHENTOLAMINE MESYLATE) PHENTOLAMINE MESYLATE (HIKMA) APPROVAL= AP YEAR= 1998
NDA 022159 (label) INN (PHENTOLAMINE MESYLATE) ORAVERSE (SEPTODONT HOLDING) APPROVAL= AP YEAR= 2008
NDA 207686 (pdf not found) INN (PHENTOLAMINE MESYLATE) PHENTOLAMINE MESYLATE (PRECISION DOSE INC) APPROVAL= AP YEAR= 2017
NDA 217064 (label) INN (PHENTOLAMINE MESYLATE) RYZUMVI (FAMYGEN LIFE SCI) APPROVAL= AP YEAR= 2023